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Gene Review

LCN6  -  lipocalin 6

Macaca mulatta

 
 
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High impact information on LCN6

  • Immunohistochemical staining revealed that LCN6 protein is abundant in the caput epithelium and lumen [1].
  • Northern hybridization analysis of LCN6 mRNA expression in sham-operated, castrated and testosterone replaced rhesus monkeys suggests mRNA levels are little affected 6 days after castration [1].
  • Predominant expression in the epididymis and location on sperm surface are consistent with a role for LCN6 in male fertility [1].
  • Immunofluorescent staining of human spermatozoa shows LCN6 located on the head and tail of spermatozoa with the highest concentration of LCN6 on the post-acrosomal region of the head, where it appeared aggregated into large patches [1].
  • CONCLUSIONS: LCN6 is a novel lipocalin closely related to Lcn5 and Lcn8 and these three genes are likely products of gene duplication events that predate rodent-primate divergence [1].

References

  1. LCN6, a novel human epididymal lipocalin. Hamil, K.G., Liu, Q., Sivashanmugam, P., Anbalagan, M., Yenugu, S., Soundararajan, R., Grossman, G., Rao, A.J., Birse, C.E., Ruben, S.M., Richardson, R.T., Zhang, Y.L., O'Rand, M.G., Petrusz, P., French, F.S., Hall, S.H. Reprod. Biol. Endocrinol. (2003) [Pubmed]
 
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