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Gene Review:

NDRG3 - NDRG family member 3

Homo sapiens

Synonyms: N-myc downstream-regulated gene 3 protein, Protein NDRG3

Zhao, W. et al., Qu, X. et al., Zhou, R.H. et al.

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High impact information on NDRG3

Here, we cloned two human cDNAs encoding NDRG3 and NDRG4, which are homologous to NDRG1 [1].
Expression of the fusion proteins NDRG2/GFP, NDRG3/GFP and NDRG4/GFP in COS-7 cells showed that all of them are cytosolic proteins [2].
We report the cloning and expression pattern of a novel N-myc downstream-regulated gene 3 (NDRG3), located on human chromosome 20q11.21-11.23 [3].
The NDRG3 cDNA is 2588 base pair in length, encoding a 363 amino acid polypeptide highly related to mouse Ndr3 protein [3].
Northern blot reveals that NDRG3 is highly expressed in testis, prostate and ovary [3].

Biological context of NDRG3

By in situ hybridization, the NDRG3 mRNA was localized to the outer layers of seminiferous epithelium, indicating that it may play a role in spermatogenesis [3].

References

Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. Zhou, R.H., Kokame, K., Tsukamoto, Y., Yutani, C., Kato, H., Miyata, T. Genomics (2001) [Pubmed]
Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Qu, X., Zhai, Y., Wei, H., Zhang, C., Xing, G., Yu, Y., He, F. Mol. Cell. Biochem. (2002) [Pubmed]
Cloning and expression pattern of the human NDRG3 gene. Zhao, W., Tang, R., Huang, Y., Wang, W., Zhou, Z., Gu, S., Dai, J., Ying, K., Xie, Y., Mao, Y. Biochim. Biophys. Acta (2001) [Pubmed]

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AgaP_AGAP008821	Anopheles gambiae str. PEST
NDL3	Arabidopsis thaliana
NDL1	Arabidopsis thaliana
NDRG3	Bos taurus
Y48G10A.3	Caenorhabditis elegans
NDRG3	Canis lupus familiaris
ndrg3b	Danio rerio
ndrg3a	Danio rerio
MESK2	Drosophila melanogaster
Ndrg3	Mus musculus
Os02g0224800	Oryza sativa Japonica Group
Os06g0563000	Oryza sativa Japonica Group
Os01g0192600	Oryza sativa Japonica Group
NDRG3	Pan troglodytes
ndrg4	Xenopus (Silurana) tropicalis

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