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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PITPNM2  -  phosphatidylinositol transfer protein,...

Homo sapiens

Synonyms: KIAA1457, Membrane-associated phosphatidylinositol transfer protein 2, NIR-3, NIR3, PITPnm 2, ...
 
 
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Disease relevance of PITPNM2

  • In contrast, Nir2 and Nir3 were homogeneously distributed in undifferentiated neuroblasts and ganglion cells at birth and later became distinctly distributed in newly differentiated neuronal cells [1].
 

High impact information on PITPNM2

  • In the adult rat retina, Nir2 was preferentially localized to the somata of all classes of retinal neurons, whereas Nir3 was highly expressed in the synaptic terminals [1].
 

Biological context of PITPNM2

 

Anatomical context of PITPNM2

  • In photoreceptor cells, both Nir2 and Nir3 were found to be highly expressed in the inner segments but were not detectably expressed in the outer segments [1].

References

  1. Cellular and developmental distribution of human homologues of the Drosophilia rdgB protein in the rat retina. Tian, D., Lev, S. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  2. Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3. Ocaka, L., Spalluto, C., Wilson, D.I., Hunt, D.M., Halford, S. Cytogenet. Genome Res. (2005) [Pubmed]
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