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Gene Review

rdgB  -  retinal degeneration B

Drosophila melanogaster

Synonyms: CG11111, Dmel\CG11111, DrdgB, DrdgBalpha, PITP, ...
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Disease relevance of rdgB


Psychiatry related information on rdgB


High impact information on rdgB


Biological context of rdgB

  • The photopigment kinetics of dark-reared rdgB flies appear normal in vitro by spectrophotometric measurements, and in vivo by measurements of the M potential [9].
  • We also examined the extent to which two previously identified visual transduction mutations suppressed rdgB retinal degeneration [10].
  • Through the isolation and analysis of X-ray-induced rdgB alleles, the cytogenetic position of the gene was determined to be the 12C1 salivary region [2].
  • However, loss of protein kinase C (inaC209), which blocks photoreceptor cell deactivation, desensitization, and light adaptation, failed to suppress rdgB degeneration under normal light conditions [10].
  • Electrophysiological recordings from the adult antenna indicate that rdgB is required for normal response in the peripheral olfactory system: some rdgB mutants show a delayed return to the resting potential following stimulation with ethyl acetate vapor [4].

Anatomical context of rdgB

  • The defects in the rdgA and rdgB mutants were localized by the study of genetic mosaics to the photoreceptor cells [9].
  • These results indicate that the rdgB protein is normally localized to the SRC membranes and probably adjacent photoreceptive membranes, suggesting the involvement of the rdgB protein in the phosphatidylinositol transfer between SRC and photoreceptive membranes [11].
  • The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling [12].
  • A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus [13].

Associations of rdgB with chemical compounds

  • Vitamin A deprivation and genetic elimination of the lysosomal enzyme acid phosphatase alsoprotect the photoreceptors of rdgB flies against light-induced damage [9].
  • Further, the (+)-cis isomer was approximately 50 times more effective than the (-)-cis isomer in blocking the Ca2+ spikes, indicating that diltiazem action on the rdgB eye is mediated by means of blocking voltage-sensitive Ca2+ channels, rather than by blocking the light-sensitive channels [14].
  • Application of the Ca(2+)-channel blockers (+)-cis-diltiazem and verapamil hydrochloride to the eyes of rdgB flies over a 7-day period largely inhibited light-dependent degeneration of the photoreceptor cells [14].
  • We propose that the Nir and rdgB proteins represent a new family of evolutionarily conserved PYK2-binding proteins that play a role in the control of calcium and phosphoinositide metabolism downstream of G-protein-coupled receptors [15].

Other interactions of rdgB


Analytical, diagnostic and therapeutic context of rdgB


  1. The Drosophila dgq gene encodes a G alpha protein that mediates phototransduction. Lee, Y.J., Shah, S., Suzuki, E., Zars, T., O'Day, P.M., Hyde, D.R. Neuron (1994) [Pubmed]
  2. Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene. Vihtelic, T.S., Hyde, D.R., O'Tousa, J.E. Genetics (1991) [Pubmed]
  3. Cloning and characterization of human homologue of Drosophila retinal degeneration B: a candidate gene for degenerative retinal diseases. Guo, J., Yu, F.X. Dev. Genet. (1997) [Pubmed]
  4. The rdgB gene of Drosophila: a link between vision and olfaction. Woodard, C., Alcorta, E., Carlson, J. J. Neurogenet. (1992) [Pubmed]
  5. Ectopic expression of a minor Drosophila opsin in the major photoreceptor cell class: distinguishing the role of primary receptor and cellular context. Zuker, C.S., Mismer, D., Hardy, R., Rubin, G.M. Cell (1988) [Pubmed]
  6. Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. Smith, D.P., Ranganathan, R., Hardy, R.W., Marx, J., Tsuchida, T., Zuker, C.S. Science (1991) [Pubmed]
  7. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Hardie, R.C., Raghu, P., Moore, S., Juusola, M., Baines, R.A., Sweeney, S.T. Neuron (2001) [Pubmed]
  8. The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation. Milligan, S.C., Alb, J.G., Elagina, R.B., Bankaitis, V.A., Hyde, D.R. J. Cell Biol. (1997) [Pubmed]
  9. Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process. Harris, W.A., Stark, W.S. J. Gen. Physiol. (1977) [Pubmed]
  10. Isolation and characterization of Drosophila retinal degeneration B suppressors. Paetkau, D.W., Elagin, V.A., Sendi, L.M., Hyde, D.R. Genetics (1999) [Pubmed]
  11. Immunolocalization of a Drosophila phosphatidylinositol transfer protein (rdgB) in normal and rdgA mutant photoreceptor cells with special reference to the subrhabdomeric cisternae. Suzuki, E., Hirosawa, K. Journal of electron microscopy. (1994) [Pubmed]
  12. The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Lev, S. Exp. Cell Res. (2004) [Pubmed]
  13. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. Lu, C., Vihtelic, T.S., Hyde, D.R., Li, T. J. Neurosci. (1999) [Pubmed]
  14. Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila. Sahly, I., Bar Nachum, S., Suss-Toby, E., Rom, A., Peretz, A., Kleiman, J., Byk, T., Selinger, Z., Minke, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  15. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev, S., Hernandez, J., Martinez, R., Chen, A., Plowman, G., Schlessinger, J. Mol. Cell. Biol. (1999) [Pubmed]
  16. The cAMP transduction cascade mediates olfactory reception in Drosophila melanogaster. Gomez-Diaz, C., Martin, F., Alcorta, E. Behav. Genet. (2004) [Pubmed]
  17. Phorbol ester induces photoreceptor-specific degeneration in a Drosophila mutant. Minke, B., Rubinstein, C.T., Sahly, I., Bar-Nachum, S., Timberg, R., Selinger, Z. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  18. Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene. Aikawa, Y., Hara, H., Watanabe, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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