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Gene Review:

SH3RF1 - SH3 domain containing ring finger 1

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase SH3RF1, KIAA1494, POSH, Plenty of SH3s, Protein POSH, ...

Alroy, I. et al., Foss, T.D.

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Disease relevance of SH3RF1

Now, we report an essential role for human ubiquitin ligase POSH (Plenty of SH3s; hPOSH), a trans-Golgi network-associated protein, in the targeting of HIV-1 to the plasma membrane [1].
Together, our results identify a previously undescribed step in HIV biogenesis and suggest a direct function for hPOSH-mediated ubiquitination in protein sorting at the trans-Golgi network [1].
Breast cancer awareness: Star, Posh, Hot and Prime [2].

High impact information on SH3RF1

Reintroduction of native, but not a RING finger mutant, hPOSH restores virus release and Gag plasma membrane localization in hPOSH-depleted cells [1].

Anatomical context of SH3RF1

Small inhibitory RNA-mediated silencing of hPOSH ablates virus secretion and Gag plasma membrane localization [1].

References

The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production. Alroy, I., Tuvia, S., Greener, T., Gordon, D., Barr, H.M., Taglicht, D., Mandil-Levin, R., Ben-Avraham, D., Konforty, D., Nir, A., Levius, O., Bicoviski, V., Dori, M., Cohen, S., Yaar, L., Erez, O., Propheta-Meiran, O., Koskas, M., Caspi-Bachar, E., Alchanati, I., Sela-Brown, A., Moskowitz, H., Tessmer, U., Schubert, U., Reiss, Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Breast cancer awareness: Star, Posh, Hot and Prime. Foss, T.D. British journal of nursing (Mark Allen Publishing) (2006) [Pubmed]

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