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Chemical Compound Review

Premier     N-[(2-chloro-6-fluoro- phenyl)methyl]-N...

Synonyms: Flumetalin, FLUMETRALIN, Flumetraline, Prime+, PS1211_SUPELCO, ...
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Disease relevance of Flumetraline


Psychiatry related information on Flumetraline

  • The Prime Minister, Mrs Thatcher, and dementia [5].
  • RESULTS: Main effects for Cue exposure but not Prime were found for the DAQ total and the subscales Mild desires (positively reinforcing items) and Strong desires/intentions but not Negative reinforcement (negatively reinforcing items) and Controllability; however, there was no interaction [6].
  • The effect of Prime Minister Anthony Eden's illness on his decision-making during the Suez crisis [7].
  • It is concluded that Mystery and Prime grapes have good organoleptic quality if harvested at SSC levels of >14% [8].
  • OBJECTIVE: To examine the dietary habits of professional soccer players at two Scottish Premier League clubs during the competitive season [9].

High impact information on Flumetraline


Chemical compound and disease context of Flumetraline

  • This study of pediatric patients was intended to determine the suitability of stool PCR and two antigen enzyme immunoassays (EIAs; Premier Platinum HpSA and the novel FemtoLab H. pylori), which detect Helicobacter pylori antigens in feces, as pretreatment diagnostic tools and especially as posttreatment control [15].
  • A commercially available enzyme immunoassay (EIA) for the detection of Clostridium difficile toxin A (Premier Toxin A EIA, Meridian Diagnostics, Cincinnati, Ohio) was compared with tissue culture cytotoxicity assay, enterotoxigenic culture, and latex agglutination test for the laboratory diagnosis of C difficile-associated disease [16].
  • A National Disaster Management Authority has been constituted which aims to provide national guidelines and is headed by the Prime Minister of India. It is the highest decision-making body for the management of disasters in the country [17].

Biological context of Flumetraline

  • The 'Prime' sequence is included in vector cloning sites and cDNA and PCR primers [18].
  • This paper describes the construction of 'Prime' cloning vectors, which include phage lambda and plasmid vectors useful for functional cloning in oocytes, yeast, and mammalian cells, and their use in a 'Prime' cloning system [18].
  • In contrast, extracts from Solist and Prime & Bond 2.1 had very small effects on cell proliferation; these elutes contained small amounts of released chemical compounds [19].
  • RESULTS: Sensitivity, specificity, positive and negative predictive values were 94%, 96%, 94% and 96% for the urea breath test; 97%, 64%, 66% and 97% for serology; 86%, 100%, 100% and 91%, for FemtoLab H. pylori; 58%, 96%, 91% and 76% for Premier Platinum HpSA and 61%, 78%, 74% and 67% for Simple H. pylori [20].
  • In June this year, United States President Clinton and British Prime Minister Blair jointly announced that the human genome had been sequenced [21].

Anatomical context of Flumetraline

  • The Premier enzyme immunoassay (Meridian Diagnostics, Inc., Cincinnati, Ohio) was compared with a latex agglutination assay (CALAS; Meridian) for the ability to detect cryptococcal capsular polysaccharide antigen (CrAg) in serum and cerebrospinal fluid (CSF) [22].
  • It was the aim of our study to investigate the composition and cytotoxicity of aqueous elutes from five dentin adhesives currently used in clinical practice: Solobond Plustrade mark, Solisttrade mark, Scotchbond Multipurposetrade mark, Syntac SCtrade mark, and Prime & Bondtrade mark 2 [19].
  • The molars were randomly assigned to four groups: control and three experimental groups-Micro Prime, Glauma Desentizer and Cervitec [23].
  • METHODS: Smear-layer covered dentin specimens produced from sound premolars, were acid-etched and analyzed by micro-MIR FTIR spectroscopy, before and after treatment with the single-bottle adhesives One-Step, Prime and Bond 2.1, Scotchbond 1 and Syntac-Sprint [24].
  • The difference between permanent and primary teeth groups for gingival values of the Prime and Bond 2.1 group U=22.5, p=0.0355 and the Scotchbond Multipurpose group U=24.0, p=0.0406 were statistically significant [25].

Associations of Flumetraline with other chemical compounds

  • After the development of an enzyme immunoassay based on polyclonal antibodies (Premier Platinum HpSA) a monoclonally based test has recently been developed (FemtoLab H. pylori) [26].
  • With the use of the products Ariston Liner, Etch & Prime 3.0, Optibond Solo, Prime & Bond NT, Scotchbond 1, and Syntac Sprint, test specimens were prepared according to the manufacturers' instructions and transferred into a culture medium [27].
  • There were no significant differences between the occlusal and gingival microleakage values in either primary or permanent teeth with Prime and Bond 2.1, Fuji Bond LC and Probond except the difference at Scotchbond Multipurpose in primary teeth [25].
  • INTERVENTIONS: Subjects sat in 3 manual wheelchairs: standard setup E&J Premier (S1), standard setup Quickie Breezy (S2), and test configuration Quickie TNT (T) with posterior seat inclination and a low backrest set perpendicular to the floor [28].
  • Dentin adhesives of the third--(with self-etching primer: ART Bond, Syntac Classic), fourth--(with total etching: Scotchbond Multi-Purpose Plus), and fifth-generation (one-bottle adhesives: Syntac Single Component, Prime & Bond 2.1) were used in combination with one hybrid composite (Tetric) or luting composite (Variolink Low) [29].

Gene context of Flumetraline

  • Probes were labelled using "Gene Image Random Prime Labelling Protocol" and COX expression was measured by flow cytometry [30].
  • The analyzer is very easy to use; the simplicity and the convenience of only one consumable make the GEM Premier 3000 very suitable for a STAT laboratory or for POCT [31].
  • RESULTS: The mean MTBS for Prime & Bond NT specimens was 15.2+/-13.1 MPa [32].
  • The aim of the present study was to investigate the effects of three dentin bonding agents, Clearfil SE Bond, Prime & Bond NT, and Single Bond on the expression of COX-2 mRNA gene and protein in cultured human gingival fibroblasts [33].
  • We report the results of simultaneous testing of 700 fresh stool specimens by the tissue culture cytotoxin assay and four EIAs (Bartels Prima System C. difficile Toxin A EIA, Cambridge Biotech Cytoclone A+B EIA, Meridian Diagnostics Premier C. difficile Toxin A EIA, and TechLab C. difficile Tox-A Test EIA) [34].

Analytical, diagnostic and therapeutic context of Flumetraline

  • H. pylori infection was evaluated by the presence of IgG antibodies using the Premier enzyme immunoassay kit (Meridian Diagnostics Inc., Cincinnati, OH) [35].
  • An enzyme-linked immunosorbent assay for the detection of Shiga toxins (Premier EHEC assay; Meridian Diagnostics, Inc.) was compared to conventional sorbitol-MacConkey culture for the recovery of enterohemorrhagic Escherichia coli [2].
  • Consecutive stool specimens (n = 200) from 133 patients were examined by cytotoxin assay, by culture of C. difficile on cycloserine-cefoxitin-fructose agar, and by toxin detection using four rapid immunoassay systems (Oxoid Toxin A test, ImmunoCard Toxin A test, TechLab Tox A/B II test, and Premier Toxins A&B test) [36].
  • Comparative evaluation of commercial Premier EIA and microimmunodiffusion and complement fixation tests for Coccidioides immitis antibodies [37].
  • We find that at sequence identities >40%, all packages give similar (and satisfactory) results; at lower sequence identities (<25%), the sequence alignments generated by Profit and Prime, which incorporate structural information in their sequence alignment, stand out from the rest [38].


  1. Adenovirus-based Prime-boost Immunization for Rapid Vaccination Against Anthrax. McConnell, M.J., Hanna, P.C., Imperiale, M.J. Mol. Ther. (2007) [Pubmed]
  2. Evaluation of the premier EHEC assay for detection of Shiga toxin-producing Escherichia coli. Kehl, K.S., Havens, P., Behnke, C.E., Acheson, D.W. J. Clin. Microbiol. (1997) [Pubmed]
  3. Laboratory diagnosis of Clostridium difficile-associated diarrhea and colitis: usefulness of Premier Cytoclone A+B enzyme immunoassay for combined detection of stool toxins and toxigenic C. difficile strains. Lozniewski, A., Rabaud, C., Dotto, E., Weber, M., Mory, F. J. Clin. Microbiol. (2001) [Pubmed]
  4. Are minimally invasive techniques for ablation of breast cancer ready for "Prime Time"? Copeland, E.M., Bland, K.I. Ann. Surg. Oncol. (2004) [Pubmed]
  5. The Prime Minister, Mrs Thatcher, and dementia. Fuller, G.N., Meeran, K. Lancet (1991) [Pubmed]
  6. The effects of alcohol cues and an alcohol priming dose on a multi-factorial measure of subjective cue reactivity in social drinkers. Schulze, D., Jones, B.T. Psychopharmacology (Berl.) (1999) [Pubmed]
  7. The effect of Prime Minister Anthony Eden's illness on his decision-making during the Suez crisis. Lord Owen, n.u.l.l. QJM : monthly journal of the Association of Physicians. (2005) [Pubmed]
  8. Factors affecting taste scores of early season seedless table grape cv. Mystery and Prime. Sonego, L., Lurie, S., Zuthi, Y., Kaplonov, T., Ben-Arie, R., Kosto, I. J. Agric. Food Chem. (2002) [Pubmed]
  9. Energy and macronutrient intakes of professional football (soccer) players. Maughan, R.J. British journal of sports medicine. (1997) [Pubmed]
  10. Fat regulation. Prime time for neuropeptide Y. Howlett, R. Nature (1996) [Pubmed]
  11. Open letter to the Right Honourable Tony Blair, Prime Minister of the UK: public health and humanitarian effects of war on Iraq. Stephens, C. Lancet (2003) [Pubmed]
  12. Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells. Dolan, B.P., Gibbs, K.D., Ostrand-Rosenberg, S. J. Immunol. (2006) [Pubmed]
  13. Anthony Eden's (Lord Avon) biliary tract saga. Braasch, J.W. Ann. Surg. (2003) [Pubmed]
  14. Performance of Gem Premier blood gas/electrolyte analyzer evaluated. Jacobs, E., Nowakowski, M., Colman, N. Clin. Chem. (1993) [Pubmed]
  15. Two enzyme immunoassays and PCR for detection of Helicobacter pylori in stool specimens from pediatric patients before and after eradication therapy. Makristathis, A., Barousch, W., Pasching, E., Binder, C., Kuderna, C., Apfalter, P., Rotter, M.L., Hirschl, A.M. J. Clin. Microbiol. (2000) [Pubmed]
  16. The use of a commercially available enzyme immunoassay for the detection of Clostridium difficile toxin A. Gilligan, P.H., Walden, T.P., Kelly, W.F., Wait, K.J., Kraft, J.A., Willis, D.H. Arch. Pathol. Lab. Med. (1993) [Pubmed]
  17. Administrative issues involved in disaster management in India. Kaur, J. International review of psychiatry (Abingdon, England) (2006) [Pubmed]
  18. Functional cloning vectors for use in directional cDNA cloning using cohesive ends produced with T4 DNA polymerase. Kuijper, J.L., Wiren, K.M., Mathies, L.D., Gray, C.L., Hagen, F.S. Gene (1992) [Pubmed]
  19. Aqueous extracts from dentin adhesives contain cytotoxic chemicals. Geurtsen, W., Spahl, W., Müller, K., Leyhausen, G. J. Biomed. Mater. Res. (1999) [Pubmed]
  20. Usefulness of non-invasive tests for diagnosing Helicobacter pylori infection in patients undergoing dialysis for chronic renal failure. López, T., Quesada, M., Almirall, J., Sanfeliu, I., Segura, F., Calvet, X. Helicobacter (2004) [Pubmed]
  21. Just how long can we live? Sutherland, G.R. Med. J. Aust. (2000) [Pubmed]
  22. Evaluation of an enzyme immunoassay for detection of cryptococcal capsular polysaccharide antigen in serum and cerebrospinal fluid. Frank, U.K., Nishimura, S.L., Li, N.C., Sugai, K., Yajko, D.M., Hadley, W.K., Ng, V.L. J. Clin. Microbiol. (1993) [Pubmed]
  23. Effect of desensitizers on the bond strength of a self-etching adhesive system to caries-affected dentin on the gingival wall. Sengun, A., Koyuturk, A.E., Sener, Y., Ozer, F. Operative dentistry. (2005) [Pubmed]
  24. Heterogeneous distribution of single-bottle adhesive monomers in the resin-dentin interdiffusion zone. Eliades, G., Vougiouklakis, G., Palaghias, G. Dental materials : official publication of the Academy of Dental Materials. (2001) [Pubmed]
  25. Penetration of radiocalcium at the margins of resin and glass ionomer dentine bonding agents in primary and permanent teeth. Tulunoglu, O., Tulunoglu, I., Ulusu, T., Genç, Y. Journal of dentistry. (2000) [Pubmed]
  26. Comparison of two enzyme immunoassays for the assessment of Helicobacter pylori status in stool specimens after eradication therapy. Leodolter, A., Peitz, U., Ebert, M.P., Agha-Amiri, K., Malfertheiner, P. Am. J. Gastroenterol. (2002) [Pubmed]
  27. Cytotoxicity of modern dentin adhesives--in vitro testing on gingival fibroblasts. Szep, S., Kunkel, A., Ronge, K., Heidemann, D. J. Biomed. Mater. Res. (2002) [Pubmed]
  28. Wheelchair configuration and postural alignment in persons with spinal cord injury. Hastings, J.D., Fanucchi, E.R., Burns, S.P. Archives of physical medicine and rehabilitation. (2003) [Pubmed]
  29. Dentin bond strength and marginal adaptation: direct composite resins vs ceramic inlays. Frankenberger, R., Sindel, J., Krämer, N., Petschelt, A. Operative dentistry. (1999) [Pubmed]
  30. Flow cytometric analysis of the in situ hybridization of cyclooxygenase isoforms in mesangial cells treated with cyclosporine A. Pérez de Hornedo, J., Calvino Fernández, M., de Arriba de la Fuente, G., del Reino Fernández, P., Parra Cid, T., Benito Martinez, S. Cytometry. Part A : the journal of the International Society for Analytical Cytology. (2006) [Pubmed]
  31. Evaluation of the blood gas analyzer Gem PREMIER 3000. Bénéteau-Burnat, B., Bocque, M.C., Lorin, A., Martin, C., Vaubourdolle, M. Clin. Chem. Lab. Med. (2004) [Pubmed]
  32. Microtensile bond strength of total-etch and self-etch adhesives to the enamel walls of Class V cavities. Kelsey, W.P., Latta, M.A., Vargas, M.A., Carroll, L.R., Armstrong, S.R. American journal of dentistry. (2005) [Pubmed]
  33. Induction of cyclooxygenase-2 mRNA and protein expression by dentin bonding agents in human gingival fibroblasts. Huang, F.M., Chang, Y.C. Journal of biomedical materials research. Part B, Applied biomaterials. (2004) [Pubmed]
  34. Comparison of four commercially available rapid enzyme immunoassays with cytotoxin assay for detection of Clostridium difficile toxin(s) from stool specimens. Merz, C.S., Kramer, C., Forman, M., Gluck, L., Mills, K., Senft, K., Steiman, I., Wallace, N., Charache, P. J. Clin. Microbiol. (1994) [Pubmed]
  35. Helicobacter pylori and malignant lymphoma in Spain. de Sanjose, S., Dickie, A., Alvaro, T., Romagosa, V., Garcia Villanueva, M., Domingo-Domenech, E., Fernandez de Sevilla, A., El-Omar, E. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  36. Evaluation of methods for detection of toxins in specimens of feces submitted for diagnosis of Clostridium difficile-associated diarrhea. O'Connor, D., Hynes, P., Cormican, M., Collins, E., Corbett-Feeney, G., Cassidy, M. J. Clin. Microbiol. (2001) [Pubmed]
  37. Comparative evaluation of commercial Premier EIA and microimmunodiffusion and complement fixation tests for Coccidioides immitis antibodies. Kaufman, L., Sekhon, A.S., Moledina, N., Jalbert, M., Pappagianis, D. J. Clin. Microbiol. (1995) [Pubmed]
  38. A comparative study of available software for high-accuracy homology modeling: from sequence alignments to structural models. Nayeem, A., Sitkoff, D., Krystek, S. Protein Sci. (2006) [Pubmed]
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