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Gene Review

PCDHB16  -  protocadherin beta 16

Homo sapiens

Synonyms: KIAA1621, ME1, PCDH-BETA16, PCDH-beta-16, PCDH3X, ...
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High impact information on PCDHB16

  • Northern blot analysis revealed that 1.3kb ME1 mRNA is highly expressed in the mouse epididymis [1].
  • The deduced amino-acid sequence of the ME1 cDNA revealed that it consists of 149 amino acid residues, which contain a signal peptide characteristic of secretory proteins, six cysteine residues and a proline-rich region conserved in the orthologous proteins [1].
  • The reduction of the molecular mass of the recombinant ME1 protein with the digestion of glycopeptidase A indicated that it is modified by Asn-linked glycosylation [1].

Anatomical context of PCDHB16

  • Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1 [1].

Analytical, diagnostic and therapeutic context of PCDHB16

  • Out of the 32 residues comprising the transmembrane helix of GpA, five amino acids were mutated; the resulting protein, ME1, has been characterized in dodecyl phosphocholin (DPC) micelles by UV-vis, CD spectroscopy, gel electrophoresis, and analytical ultracentrifugation [2].
  • The expression of ME1 forms was found to be absent in B*2704 N97D by immunoprecipitation and flow cytometry of fixed and permeabilized cell experiments with the conformation-sensitive ME1 antibody [3].


  1. Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1. Nakamura, Y., Takayama, N., Minamitani, T., Ikuta, T., Ariga, H., Matsumoto, K. Gene (2000) [Pubmed]
  2. Design of a functional membrane protein by engineering a heme-binding site in glycophorin A. Cordova, J.M., Noack, P.L., Hilcove, S.A., Lear, J.D., Ghirlanda, G. J. Am. Chem. Soc. (2007) [Pubmed]
  3. The amino acid at position 97 is involved in folding and surface expression of HLA-B27. Blanco-Gelaz, M.A., Suárez-Alvarez, B., González, S., López-Vázquez, A., Martínez-Borra, J., López-Larrea, C. Int. Immunol. (2006) [Pubmed]
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