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PCDHB16  -  protocadherin beta 16

Homo sapiens

Synonyms: KIAA1621, ME1, PCDH-BETA16, PCDH-beta-16, PCDH3X, ...
 
 
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High impact information on PCDHB16

  • Northern blot analysis revealed that 1.3kb ME1 mRNA is highly expressed in the mouse epididymis [1].
  • The deduced amino-acid sequence of the ME1 cDNA revealed that it consists of 149 amino acid residues, which contain a signal peptide characteristic of secretory proteins, six cysteine residues and a proline-rich region conserved in the orthologous proteins [1].
  • The reduction of the molecular mass of the recombinant ME1 protein with the digestion of glycopeptidase A indicated that it is modified by Asn-linked glycosylation [1].
 

Anatomical context of PCDHB16

  • Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1 [1].
 

Analytical, diagnostic and therapeutic context of PCDHB16

  • Out of the 32 residues comprising the transmembrane helix of GpA, five amino acids were mutated; the resulting protein, ME1, has been characterized in dodecyl phosphocholin (DPC) micelles by UV-vis, CD spectroscopy, gel electrophoresis, and analytical ultracentrifugation [2].
  • The expression of ME1 forms was found to be absent in B*2704 N97D by immunoprecipitation and flow cytometry of fixed and permeabilized cell experiments with the conformation-sensitive ME1 antibody [3].

References

  1. Primary structure, genomic organization and expression of the major secretory protein of murine epididymis, ME1. Nakamura, Y., Takayama, N., Minamitani, T., Ikuta, T., Ariga, H., Matsumoto, K. Gene (2000) [Pubmed]
  2. Design of a functional membrane protein by engineering a heme-binding site in glycophorin A. Cordova, J.M., Noack, P.L., Hilcove, S.A., Lear, J.D., Ghirlanda, G. J. Am. Chem. Soc. (2007) [Pubmed]
  3. The amino acid at position 97 is involved in folding and surface expression of HLA-B27. Blanco-Gelaz, M.A., Suárez-Alvarez, B., González, S., López-Vázquez, A., Martínez-Borra, J., López-Larrea, C. Int. Immunol. (2006) [Pubmed]
 
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