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Gene Review:

hsf1 - heat shock transcription factor 1

Danio rerio

Synonyms: HSF, HSF1c, SO:0000704, hsf1a, hsf1b, ...

Yeh, F.L. et al., Airaksinen, S. et al., Airaksinen, S. et al., Wang, G. et al.

Airaksinen, Råbergh, Lahti, Kaatrasalo, Sistonen, Nikinmaa, Airaksinen, Jokilehto, Råbergh, Nikinmaa,

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Disease relevance of hsf1

To characterize the role of zHSF1a and zHSF1b isoforms in the regulation of the stress response in vivo, we have carried out cadmium (10-100 microM) and copper (10-30 microM) exposures in order to specify whether the disappearance of HSF1b is specific for heat stress [1].

High impact information on hsf1

Suppression of heat shock transcription factor HSF1 in zebrafish causes heat-induced apoptosis [2].
The levels of both zHSF1a and zHSF2 mRNA in zebrafish tissues were moderately increased after heat stress [3].
Similar patterns of zHSF1a and zHSF2 mRNA expression in the brain regions of developing zebrafish were detected by whole mount in situ hybridization and paraffin sectioning, suggesting that most of the two HSF gene activities were controlled by a common mechanism during the embryonic development of zebrafish [3].
Elevated temperature induces a rapid heat shock transcription factor (HSFs)-mediated expression of heat shock (hsp) genes [4].

References

Stressor-dependent regulation of the heat shock response in zebrafish, Danio rerio. Airaksinen, S., Råbergh, C.M., Lahti, A., Kaatrasalo, A., Sistonen, L., Nikinmaa, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]
Suppression of heat shock transcription factor HSF1 in zebrafish causes heat-induced apoptosis. Wang, G., Huang, H., Dai, R., Lee, K.Y., Lin, S., Mivechi, N.F. Genesis (2001) [Pubmed]
Cloning of zebrafish (Danio rerio) heat shock factor 2 (HSF2) and similar patterns of HSF2 and HSF1 mRNA expression in brain tissues. Yeh, F.L., Hsu, L.Y., Lin, B.A., Chen, C.F., Li, I.C., Tsai, S.H., Hsu, T. Biochimie (2006) [Pubmed]
Heat- and cold-inducible regulation of HSP70 expression in zebrafish ZF4 cells. Airaksinen, S., Jokilehto, T., Råbergh, C.M., Nikinmaa, M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]

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HSF1	Bos taurus
HSF1	Canis lupus familiaris
HSF1	Homo sapiens
HSF1	Macaca mulatta
Hsf1	Mus musculus
Hsf1	Rattus norvegicus
LOC100489822	Xenopus (Silurana) tropicalis

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