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Gene Review

serpinh1b  -  serpin peptidase inhibitor, clade H (heat...

Danio rerio

Synonyms: SO:0000704, cb216, hsp, hsp47, id:ibd5060, ...
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Disease relevance of hsp47


High impact information on hsp47

  • Members of the zebrafish hsp47, hsp70 and hsp90 gene families have been cloned and shown to be closely related to their counterparts in higher vertebrates [2].
  • Both the hsp47 and hsp90 genes are expressed in a highly tissue-restricted manner during normal development [2].
  • In contrast, ethanol exposure resulted in strong upregulation of the hsp47 gene whereas hsp70 mRNA levels increased only slightly following the same treatment [3].
  • Surprisingly, no hsp47 mRNA is detectable in the strongly col2a1-expressing cells of the floor plate and hypochord, indicating that the two genes are not strictly co-regulated [4].
  • hsp47 and hsp70 gene expression is differentially regulated in a stress- and tissue-specific manner in zebrafish embryos [3].

Biological context of hsp47


Anatomical context of hsp47

  • Strong expression of hsp47 mRNA is co-incident predominantly with expression of the type II collagen gene (col2a1) in a number of chondrogenic and non-chondrogenic tissues including the notochord, otic vesicle and developing fins [4].
  • Whole-mount in situ hybridization analysis revealed that hsp47 mRNA was expressed predominantly in precartilagenous cells, as well as several other connective tissue cell populations within the embryo following exposure to either stress. hsp70 mRNA displayed a very different cell-specific distribution [3].
  • Thus, it is likely that hsp47 in zebrafish is also localized to the endoplasmic reticulum and may play a similar role to its counterpart in higher vertebrates [5].
  • Northern blot analysis revealed that the hsp47 gene is expressed at relatively low levels in embryos during normal development but is strongly induced following exposure to heat shock at the gastrula, midsomitogenesis, 2-day, and 3-day larval stages [5].

Other interactions of hsp47


Analytical, diagnostic and therapeutic context of hsp47

  • Using Northern blot analysis, we found that levels of hsp47 and hsp70 mRNA were dramatically elevated during heat shock in 2-day-old embryos [3].


  1. Heat- and cold-inducible regulation of HSP70 expression in zebrafish ZF4 cells. Airaksinen, S., Jokilehto, T., Råbergh, C.M., Nikinmaa, M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]
  2. Heat shock protein gene expression during embryonic development of the zebrafish. Krone, P.H., Sass, J.B., Lele, Z. Cell. Mol. Life Sci. (1997) [Pubmed]
  3. hsp47 and hsp70 gene expression is differentially regulated in a stress- and tissue-specific manner in zebrafish embryos. Lele, Z., Engel, S., Krone, P.H. Dev. Genet. (1997) [Pubmed]
  4. Expression of genes encoding the collagen-binding heat shock protein (Hsp47) and type II collagen in developing zebrafish embryos. Lele, Z., Krone, P.H. Mech. Dev. (1997) [Pubmed]
  5. Cloning and characterization of a cDNA encoding the collagen-binding stress protein hsp47 in zebrafish. Pearson, D.S., Kulyk, W.M., Kelly, G.M., Krone, P.H. DNA Cell Biol. (1996) [Pubmed]
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