Gene Review:
HSF1 - heat shock transcription factor 1
Homo sapiens
Synonyms:
HSF 1, HSTF 1, HSTF1, Heat shock factor protein 1, Heat shock transcription factor 1
- Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. Schett, G., Redlich, K., Xu, Q., Bizan, P., Gröger, M., Tohidast-Akrad, M., Kiener, H., Smolen, J., Steiner, G. J. Clin. Invest. (1998)
- Molecular cloning and expression of a human heat shock factor, HSF1. Rabindran, S.K., Giorgi, G., Clos, J., Wu, C. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Sistonen, L., Sarge, K.D., Morimoto, R.I. Mol. Cell. Biol. (1994)
- Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. Schett, G., Steiner, C.W., Gröger, M., Winkler, S., Graninger, W., Smolen, J., Xu, Q., Steiner, G. FASEB J. (1999)
- Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia. Wang, J.H., Yao, M.Z., Gu, J.F., Sun, L.Y., Shen, Y.F., Liu, X.Y. Biochem. Biophys. Res. Commun. (2002)
- HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. Jacobs, A.T., Marnett, L.J. J. Biol. Chem. (2009)
- Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. Guo, Y., Guettouche, T., Fenna, M., Boellmann, F., Pratt, W.B., Toft, D.O., Smith, D.F., Voellmy, R. J. Biol. Chem. (2001)
- Rapid activation of heat shock factor-1 DNA binding by H2O2 and modulation by glutathione in human neuroblastoma and Alzheimer's disease cybrid cells. Bijur, G.N., Davis, R.E., Jope, R.S. Brain Res. Mol. Brain Res. (1999)
- Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Zou, J., Guo, Y., Guettouche, T., Smith, D.F., Voellmy, R. Cell (1998)
- Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Kanei-Ishii, C., Tanikawa, J., Nakai, A., Morimoto, R.I., Ishii, S. Science (1997)
- Crystal structure of the DNA binding domain of the heat shock transcription factor. Harrison, C.J., Bohm, A.A., Nelson, H.C. Science (1994)
- Competitive inhibition of hsp70 gene expression causes thermosensitivity. Johnston, R.N., Kucey, B.L. Science (1988)
- Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. Corey, L.L., Weirich, C.S., Benjamin, I.J., Kingston, R.E. Genes Dev. (2003)
- Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress. Kim, S.A., Yoon, J.H., Lee, S.H., Ahn, S.G. J. Biol. Chem. (2005)
- Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells. Hansen, R.K., Oesterreich, S., Lemieux, P., Sarge, K.D., Fuqua, S.A. Biochem. Biophys. Res. Commun. (1997)
- Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. Fujimoto, M., Takaki, E., Hayashi, T., Kitaura, Y., Tanaka, Y., Inouye, S., Nakai, A. J. Biol. Chem. (2005)
- Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Rossi, A., Ciafrè, S., Balsamo, M., Pierimarchi, P., Santoro, M.G. Cancer Res. (2006)
- Formation of nuclear HSF1 granules varies depending on stress stimuli. Holmberg, C.I., Illman, S.A., Kallio, M., Mikhailov, A., Sistonen, L. Cell Stress Chaperones (2000)
- Molecular chaperones as HSF1-specific transcriptional repressors. Shi, Y., Mosser, D.D., Morimoto, R.I. Genes Dev. (1998)
- Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production. Ding, X.Z., Tsokos, G.C., Kiang, J.G. J. Clin. Invest. (1997)
- Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits. Yang, S.H., Nussenzweig, A., Li, L., Kim, D., Ouyang, H., Burgman, P., Li, G.C. Mol. Cell. Biol. (1996)
- Distinct stress-inducible and developmentally regulated heat shock transcription factors in Xenopus oocytes. Gordon, S., Bharadwaj, S., Hnatov, A., Ali, A., Ovsenek, N. Dev. Biol. (1997)
- Activation of heat shock factor 1 by hyperosmotic or hypo-osmotic stress is drastically attenuated in normal human fibroblasts during senescence. Lu, J., Park, J.H., Liu, A.Y., Chen, K.Y. J. Cell. Physiol. (2000)
- Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Hietakangas, V., Ahlskog, J.K., Jakobsson, A.M., Hellesuo, M., Sahlberg, N.M., Holmberg, C.I., Mikhailov, A., Palvimo, J.J., Pirkkala, L., Sistonen, L. Mol. Cell. Biol. (2003)
- Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. An effect independent of the acquisition of DNA-binding activity by the heat shock transcription factor. Elia, G., De Marco, A., Rossi, A., Santoro, M.G. J. Biol. Chem. (1996)
- Evidence that a rapidly turning over protein, normally degraded by proteasomes, regulates hsp72 gene transcription in HepG2 cells. Zhou, M., Wu, X., Ginsberg, H.N. J. Biol. Chem. (1996)
- Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. Alastalo, T.P., Hellesuo, M., Sandqvist, A., Hietakangas, V., Kallio, M., Sistonen, L. J. Cell. Sci. (2003)
- Potential targets for HSF1 within the preinitiation complex. Yuan, C.X., Gurley, W.B. Cell Stress Chaperones (2000)
- Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Housby, J.N., Cahill, C.M., Chu, B., Prevelige, R., Bickford, K., Stevenson, M.A., Calderwood, S.K. Cytokine (1999)
- Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. Xie, Y., Chen, C., Stevenson, M.A., Auron, P.E., Calderwood, S.K. J. Biol. Chem. (2002)
- Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Wang, X., Grammatikakis, N., Siganou, A., Calderwood, S.K. Mol. Cell. Biol. (2003)
- Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. Wang, X., Khaleque, M.A., Zhao, M.J., Zhong, R., Gaestel, M., Calderwood, S.K. J. Biol. Chem. (2006)
- JNK phosphorylates the HSF1 transcriptional activation domain: role of JNK in the regulation of the heat shock response. Park, J., Liu, A.Y. J. Cell. Biochem. (2001)
- Enhancement of apoptosis by nitric oxide released from alpha-phenyl-tert-butyl nitrone under hyperthermic conditions. Cui, Z.G., Kondo, T., Matsumoto, H. J. Cell. Physiol. (2006)
- Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. Hong, Y., Rogers, R., Matunis, M.J., Mayhew, C.N., Goodson, M.L., Park-Sarge, O.K., Sarge, K.D., Goodson, M. J. Biol. Chem. (2001)
- Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. He, H., Soncin, F., Grammatikakis, N., Li, Y., Siganou, A., Gong, J., Brown, S.A., Kingston, R.E., Calderwood, S.K. J. Biol. Chem. (2003)
- Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF. Liu, X.D., Liu, P.C., Santoro, N., Thiele, D.J. EMBO J. (1997)
- The RET receptor is linked to stress response pathways. Myers, S.M., Mulligan, L.M. Cancer Res. (2004)
- Pervanadate induces the hyperphosphorylation but not the activation of human heat shock factor 1. Park, J., Liu, A.Y. J. Cell. Physiol. (2000)
- Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. Somasundaram, T., Bhat, S.P. J. Biol. Chem. (2004)
- Activation of heat-shock transcription factor 1 in heated Chinese hamster ovary cells is dependent on the cell cycle and is inhibited by sodium vanadate. He, L., Fox, M.H. Radiat. Res. (1999)
- Higher induction of heat shock protein 72 by heat stress in cisplatin-resistant than in cisplatin-sensitive cancer cells. Abe, T., Gotoh, S., Higashi, K. Biochim. Biophys. Acta (1999)
- Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. Roccisana, J.L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G.D., Reddy, S.V. J. Biol. Chem. (2004)
- Regulation of the HIV1 long terminal repeat by mutant heat shock factor. Ignatenko, N.A., Gerner, E.W. Exp. Cell Res. (2003)