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Shank3  -  SH3/ankyrin domain gene 3

Mus musculus

Synonyms: AI841104, Kiaa1650, ProSAP2, Proline-rich synapse-associated protein 2, Prosap2, ...
 
 
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High impact information on Shank3

  • Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism [1].
  • Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins [2].
  • Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin [3].
  • The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells [4].
  • Using the glutathione S-transferase pull-down assay and immunoprecipitation technique we demonstrated that the GluR1 subunit directly binds to the PDZ domain of Shank3 via its carboxyl terminal PDZ-binding motif [5].
  • Mutation/deletion approaches indicate that these effects require interactions of Shank3 with the glutamate receptor complex [6].
  • Here, we report that knock-down of Shank3/prolinerich synapse-associated protein-2 by RNA interference reduces spine density in hippocampal neurons [6].
  • Moreover, transgene expression of Shank 3 is sufficient to induce functional dendritic spines in aspiny cerebellar neurons [6]
 

Mouse Models of Shank3

  • Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism [1].

 

Associations of Shank3 with chemical compounds

  • Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor [5].
 

Regulatory relationships of Shank3

  • Furthermore, we show that Ret9 but not Ret51 induces epithelial cells to form branched tubular structures in three-dimensional cultures in a Shank3-dependent manner [4].

 

 

References

  1. Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism. Bangash, M.A., Park, J.M., Melnikova, T., Wang, D., Jeon, S.K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H.E., Kee, S.E., Tu, J.C., Hu, J.H., Petralia, R.S., Linden, D.J., Powell, C.M., Savonenko, A., Xiao, B., Worley, P.F. Cell. (2011) [Pubmed]
  2. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Tu, J.C., Xiao, B., Naisbitt, S., Yuan, J.P., Petralia, R.S., Brakeman, P., Doan, A., Aakalu, V.K., Lanahan, A.A., Sheng, M., Worley, P.F. Neuron. (1999) [Pubmed]
  3. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Naisbitt, S., Kim, E., Tu, J.C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R.J., Worley, P.F., Sheng, M. Neuron. (1999) [Pubmed]
  4. The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. Schuetz, G., Rosário, M., Grimm, J., Boeckers, T.M., Gundelfinger, E.D., Birchmeier, W. J. Cell Biol. (2004) [Pubmed]
  5. Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. Uchino, S., Wada, H., Honda, S., Nakamura, Y., Ondo, Y., Uchiyama, T., Tsutsumi, M., Suzuki, E., Hirasawa, T., Kohsaka, S. J. Neurochem. (2006) [Pubmed]
  6. Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. Roussignol, G., Ango, F., Romorini, S., Tu, J.C., Sala, C., Worley, P.F., Bockaert, J., Fagni, L. J. Neurosci. (2005) [Pubmed]
 
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