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Shank3  -  SH3 and multiple ankyrin repeat domains 3

Rattus norvegicus

Synonyms: ProSAP2, Proline-rich synapse-associated protein 2, Prosap2, SH3 and multiple ankyrin repeat domains protein 3, SPANK-2
 
 
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High impact information on Shank3

 

Biological context of Shank3

  • The phosphorylated residues detected following in vitro phosphorylation in the presence of Ca2+/calmodulin included S-1058 on SynGAP and S-1662 and S-1668 on Shank3 [5].
 

Other interactions of Shank3

  • Coimmunoprecipitation of endogenous Abp1 and ProSAP2 and colocalization studies of Abp1 and ProSAPs in hippocampal neurons indicate the in vivo relevance of the interactions [7].

 

 

References

  1. Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism. Bangash, M.A., Park, J.M., Melnikova, T., Wang, D., Jeon, S.K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H.E., Kee, S.E., Tu, J.C., Hu, J.H., Petralia, R.S., Linden, D.J., Powell, C.M., Savonenko, A., Xiao, B., Worley, P.F. Cell. (2011) [Pubmed]
  2. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Tu, J.C., Xiao, B., Naisbitt, S., Yuan, J.P., Petralia, R.S., Brakeman, P., Doan, A., Aakalu, V.K., Lanahan, A.A., Sheng, M., Worley, P.F. Neuron. (1999) [Pubmed]
  3. Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3' untranslated region of Shank1 mRNA. Böckers, T.M., Segger-Junius, M., Iglauer, P., Bockmann, J., Gundelfinger, E.D., Kreutz, M.R., Richter, D., Kindler, S., Kreienkamp, H.J. Mol. Cell. Neurosci. (2004) [Pubmed]
  4. ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53. Bockmann, J., Kreutz, M.R., Gundelfinger, E.D., Böckers, T.M. J. Neurochem. (2002) [Pubmed]
  5. Identification of novel phosphorylation sites on postsynaptic density proteins. Jaffe, H., Vinade, L., Dosemeci, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Boeckers, T.M., Winter, C., Smalla, K.H., Kreutz, M.R., Bockmann, J., Seidenbecher, C., Garner, C.C., Gundelfinger, E.D. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  7. Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. Qualmann, B., Boeckers, T.M., Jeromin, M., Gundelfinger, E.D., Kessels, M.M. J. Neurosci. (2004) [Pubmed]
 
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