Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

JAM2 - junctional adhesion molecule 2

Homo sapiens

Synonyms: C21orf43, CD322, JAM-2, JAM-B, JAMB, ...

Ghosh, S. et al., Liang, T.W. et al., Halasz, P. et al., Padden, M. et al., Cunningham, S.A. et al.

Halasz, Fleming, Coulson, Cunningham, Rodriguez, Arrate, Tran, Brock,

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Disease relevance of JAM2

Antibody blockade of CD322 did not alter cell attachment or infectivity by human rotavirus strain RV-3, so RV-3 infection was independent of CD322 [1].

High impact information on JAM2

We have previously reported that junctional adhesion molecule 2 (JAM2) adheres to T cells through heterotypic interactions with JAM3 [2].
We confirmed VE-JAM/JAM 2 expression to be restricted to the high endothelial venule of tonsil and lymph nodes, and we further expanded the localization to the endothelium of arterioles in and around inflammatory and tumor foci [3].
Differential gene profiling studies on HBL cells showed an increased expression of genes encoding molecules involved in intercellular adhesion, such as junctional adhesion molecule 2 and cadherin-like 1 (>20- and 8-fold up-regulated, respectively) in 3D as compared with 2D cultures [4].
JAM-B was strongly expressed on a small number of large blood vessels in control and MS tissues but at too low a level for quantitative analysis [5].
CD322 expression was detected on MA104 but not Caco-2 cells [1].

References

Evaluation of specificity and effects of monoclonal antibodies submitted to the Eighth Human Leucocyte Differentiation Antigen Workshop on rotavirus-cell attachment and entry. Halasz, P., Fleming, F.E., Coulson, B.S. Cell. Immunol. (2005) [Pubmed]
JAM2 interacts with alpha4beta1. Facilitation by JAM3. Cunningham, S.A., Rodriguez, J.M., Arrate, M.P., Tran, T.M., Brock, T.A. J. Biol. Chem. (2002) [Pubmed]
Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. Liang, T.W., Chiu, H.H., Gurney, A., Sidle, A., Tumas, D.B., Schow, P., Foster, J., Klassen, T., Dennis, K., DeMarco, R.A., Pham, T., Frantz, G., Fong, S. J. Immunol. (2002) [Pubmed]
Culture of melanoma cells in 3-dimensional architectures results in impaired immunorecognition by cytotoxic T lymphocytes specific for Melan-A/MART-1 tumor-associated antigen. Ghosh, S., Rosenthal, R., Zajac, P., Weber, W.P., Oertli, D., Heberer, M., Martin, I., Spagnoli, G.C., Reschner, A. Ann. Surg. (2005) [Pubmed]
Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology. Padden, M., Leech, S., Craig, B., Kirk, J., Brankin, B., McQuaid, S. Acta Neuropathol. (2007) [Pubmed]

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