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Gene Review

JAM3  -  junctional adhesion molecule 3

Homo sapiens

Synonyms: JAM-2, JAM-3, JAM-C, JAMC, Junctional adhesion molecule 3, ...
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Disease relevance of JAM3


High impact information on JAM3


Biological context of JAM3

  • Most significantly we demonstrate up-regulation of JAM3 protein on peripheral blood lymphocytes following activation [7].
  • Within this critical region we have identified JAM3, a member of the junction adhesion molecule family, as a strong candidate gene for the cardiac phenotype on the basis that it is expressed during human cardiogenesis in the structures principally affected in hypoplastic left heart [8].
  • Here, the homophilic interaction of JAM-C is presented and functionally characterized to mediate tumor cell-endothelial cell interactions [3].
  • Mutagenesis of the only acidic residue in the C-D loop of this Ig fold, namely Asp-82, has no bearing on alpha(4)beta(1) interactions, and thus JAM2 deviates somewhat from the mechanism used by other immunoglobulin superfamily cell adhesion molecules to engage integrin [9].
  • We show that transfection of JAM-C improves the tight junctional barrier in tumor cells devoid of JAM-C expression [6].

Anatomical context of JAM3


Associations of JAM3 with chemical compounds


Regulatory relationships of JAM3

  • Previous studies have shown that key adhesive interactions between leukocyte CD11b/CD18 and basally expressed fucosylated glycoproteins followed by binding to desmosomal-associated JAM-C are key elements of the transmigration response [12].

Other interactions of JAM3


  1. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. Ebnet, K., Aurrand-Lions, M., Kuhn, A., Kiefer, F., Butz, S., Zander, K., Meyer zu Brickwedde, M.K., Suzuki, A., Imhof, B.A., Vestweber, D. J. Cell. Sci. (2003) [Pubmed]
  2. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. Orlova, V.V., Economopoulou, M., Lupu, F., Santoso, S., Chavakis, T. J. Exp. Med. (2006) [Pubmed]
  3. The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions. Santoso, S., Orlova, V.V., Song, K., Sachs, U.J., Andrei-Selmer, C.L., Chavakis, T. J. Biol. Chem. (2005) [Pubmed]
  4. The role of junctional adhesion molecule C (JAM-C) in acute pancreatitis. Vonlaufen, A., Aurrand-Lions, M., Pastor, C.M., Lamagna, C., Hadengue, A., Imhof, B.A., Frossard, J.L. J. Pathol. (2006) [Pubmed]
  5. Ectoplasmic specialization: a friend or a foe of spermatogenesis? Yan, H.H., Mruk, D.D., Lee, W.M., Cheng, C.Y. Bioessays (2007) [Pubmed]
  6. JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. Mandicourt, G., Iden, S., Ebnet, K., Aurrand-Lions, M., Imhof, B.A. J. Biol. Chem. (2007) [Pubmed]
  7. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. Arrate, M.P., Rodriguez, J.M., Tran, T.M., Brock, T.A., Cunningham, S.A. J. Biol. Chem. (2001) [Pubmed]
  8. Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis. Phillips, H.M., Renforth, G.L., Spalluto, C., Hearn, T., Curtis, A.R., Craven, L., Havarani, B., Clement-Jones, M., English, C., Stumper, O., Salmon, T., Hutchinson, S., Jackson, M.S., Wilson, D.I. Genomics (2002) [Pubmed]
  9. JAM2 interacts with alpha4beta1. Facilitation by JAM3. Cunningham, S.A., Rodriguez, J.M., Arrate, M.P., Tran, T.M., Brock, T.A. J. Biol. Chem. (2002) [Pubmed]
  10. Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. Liang, T.W., Chiu, H.H., Gurney, A., Sidle, A., Tumas, D.B., Schow, P., Foster, J., Klassen, T., Dennis, K., DeMarco, R.A., Pham, T., Frantz, G., Fong, S. J. Immunol. (2002) [Pubmed]
  11. JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. Zen, K., Babbin, B.A., Liu, Y., Whelan, J.B., Nusrat, A., Parkos, C.A. Mol. Biol. Cell (2004) [Pubmed]
  12. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Zen, K., Liu, Y., McCall, I.C., Wu, T., Lee, W., Babbin, B.A., Nusrat, A., Parkos, C.A. Mol. Biol. Cell (2005) [Pubmed]
  13. Molecular characterization of an 11q interstitial deletion in a patient with the clinical features of Jacobsen syndrome. Wenger, S.L., Grossfeld, P.D., Siu, B.L., Coad, J.E., Keller, F.G., Hummel, M. Am. J. Med. Genet. A (2006) [Pubmed]
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