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Gene Review

SPARCL1  -  SPARC-like 1 (hevin)

Homo sapiens

Synonyms: Hevin, High endothelial venule protein, MAST 9, MAST9, PIG33, ...
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Disease relevance of SPARCL1

  • Originally we identified SPARCL1 as one of the genes down regulated in human non-small cell lung cancer (NSCLC) [1].
  • Recent reports indicate that the down regulation of SPARCL1 also occurs in prostate and colon carcinomas, suggesting that SPARCL1 inactivation is a common event not only in NSCLCs but also in other tumors of epithelial origin [1].
  • Using Northern and Western blot analysis, we showed that MAST9 was down-regulated in the tumor samples of nine non-small cell lung carcinoma patients [2].
  • In the extracellular matrix of cultured osteosarcoma cells SC1 was found associated with collagen I-containing fibrils, and binding of SC1 to reconstituted collagen I fibrils could be demonstrated by immunogold labeling and electron microscopy [3].
  • In this Prospect article we summarize evidence for SPARC and hevin in the regulation of tumor cell growth, differentiation, and metastasis, and we propose that matricellular proteins such as these perform critical functions in desmoplastic responses of tumors that culminate in their dissemination and eventual colonization of other sites [4].

High impact information on SPARCL1


Biological context of SPARCL1


Anatomical context of SPARCL1

  • Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules [12].
  • Here, we show that this protein, designated hevin, is associated with basal, lateral, and apical surfaces of HEV cells, and unlike MECA-79 antigen, is not expressed on the underlying basement membrane [12].
  • Hevin-treated cells do not form focal adhesions and exhibit a rounded morphology [12].
  • Although SC1/ECM2 is normally a secreted protein, we show that it is also capable of augmenting lymphopoiesis when expressed as a transmembrane protein on fibroblasts [13].
  • A fusion protein prepared from the full length of SC1/ECM2 and Ig was found to recognize pre-B cells in a divalent cation-dependent manner, and to augment mitogen-dependent proliferation of mature B cells, as well as the cloning of pre-B cells, but to have no influence on myeloid progenitor cells [13].

Associations of SPARCL1 with chemical compounds


Regulatory relationships of SPARCL1


Other interactions of SPARCL1

  • Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis [10].
  • Interaction of myocilin with the C-terminal region of hevin [19].
  • A fusion protein prepared from the amino terminal portion of SC1/ECM2 and the constant region of human Ig preferentially bound to pre-B cells [13].
  • We present evidence for an altered collagen matrix and levels of the proteoglycan decorin in the normal dermis and dermal wound bed of hevin-null mice [20].
  • We have cloned a human Hevin cDNA from omental adipose tissue of different patients by reverse transcription polymerase chain reaction and shown a sequence variation due to a possible polymorphism at amino acid position 161 (E/G) [14].

Analytical, diagnostic and therapeutic context of SPARCL1


  1. Genomic organization and chromosomal mapping of SPARC-like 1, a gene down regulated in cancers. Isler, S.G., Schenk, S., Bendik, I., Schraml, P., Novotna, H., Moch, H., Sauter, G., Ludwig, C.U. Int. J. Oncol. (2001) [Pubmed]
  2. Characterization of MAST9/Hevin, a SPARC-like protein, that is down-regulated in non-small cell lung cancer. Bendik, I., Schraml, P., Ludwig, C.U. Cancer Res. (1998) [Pubmed]
  3. SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. Hambrock, H.O., Nitsche, D.P., Hansen, U., Bruckner, P., Paulsson, M., Maurer, P., Hartmann, U. J. Biol. Chem. (2003) [Pubmed]
  4. SPARC and tumor growth: where the seed meets the soil? Framson, P.E., Sage, E.H. J. Cell. Biochem. (2004) [Pubmed]
  5. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. Girard, J.P., Springer, T.A. Immunity (1995) [Pubmed]
  6. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. Sassetti, C., Tangemann, K., Singer, M.S., Kershaw, D.B., Rosen, S.D. J. Exp. Med. (1998) [Pubmed]
  7. Adhesion molecules of cultured hematopoietic malignancies. A calcium-dependent lectin is the principle mediator of binding to the high endothelial venule of lymph nodes. Stoolman, L.M., Ebling, H. J. Clin. Invest. (1989) [Pubmed]
  8. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. Jalkanen, S., Jalkanen, M. J. Cell Biol. (1992) [Pubmed]
  9. Self-renewal of embryonic stem cells by a small molecule. Chen, S., Do, J.T., Zhang, Q., Yao, S., Yan, F., Peters, E.C., Sch??ler, H.R., Schultz, P.G., Ding, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family. Sullivan, M.M., Sage, E.H. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  11. Evidence for transcriptional repression of SPARC-like 1, a gene downregulated in human lung tumors. Isler, S.G., Ludwig, C.U., Chiquet-Ehrismann, R., Schenk, S. Int. J. Oncol. (2004) [Pubmed]
  12. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. Girard, J.P., Springer, T.A. J. Biol. Chem. (1996) [Pubmed]
  13. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. Oritani, K., Kanakura, Y., Aoyama, K., Yokota, T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Tomiyama, Y., Matsuzawa, Y., Kincade, P.W. Blood (1997) [Pubmed]
  14. Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation. Claeskens, A., Ongenae, N., Neefs, J.M., Cheyns, P., Kaijen, P., Cools, M., Kutoh, E. Br. J. Cancer (2000) [Pubmed]
  15. Lymphopoiesis and matrix glycoprotein SC1/ECM2. Oritani, K., Kincade, P.W. Leuk. Lymphoma (1998) [Pubmed]
  16. Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Hu, M.C., Crowe, D.T., Weissman, I.L., Holzmann, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells (HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker. Saito, K., Tanaka, T., Kanda, H., Ebisuno, Y., Izawa, D., Kawamoto, S., Okubo, K., Miyasaka, M. J. Immunol. (2002) [Pubmed]
  18. Interaction between Src homology 2 domain bearing protein tyrosine phosphatase substrate-1 and CD47 mediates the adhesion of human B lymphocytes to nonactivated endothelial cells. Yoshida, H., Tomiyama, Y., Oritani, K., Murayama, Y., Ishikawa, J., Kato, H., Miyagawa Ji, J., Honma, N., Nishiura, T., Matsuzawa, Y. J. Immunol. (2002) [Pubmed]
  19. Interaction of myocilin with the C-terminal region of hevin. Li, Y., Aroca-Aguilar, J.D., Ghosh, S., Sánchez-Sánchez, F., Escribano, J., Coca-Prados, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  20. Matricellular hevin regulates decorin production and collagen assembly. Sullivan, M.M., Barker, T.H., Funk, S.E., Karchin, A., Seo, N.S., Höök, M., Sanders, J., Starcher, B., Wight, T.N., Puolakkainen, P., Sage, E.H. J. Biol. Chem. (2006) [Pubmed]
  21. SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma. Lau, C.Y., Poon, R.P., Cheung, S.T., Yu, W.C., Fan, S.T. J. Pathol. (2006) [Pubmed]
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