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Gene Review

Flnc  -  filamin C, gamma

Mus musculus

Synonyms: 1110055E19Rik, ABP-280, ABP-280-like protein, ABP-L, ABPL, ...
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Disease relevance of Flnc

  • These results suggest that KY is an intrinsic part of the protein networks underlying the molecular mechanism of several limb-girdle muscular dystrophies, particularly those where interactions between filamin C and disease causing proteins have been shown [1].
  • Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres [1].

High impact information on Flnc


Biological context of Flnc

  • To enhance our understanding of this cell population, we examined the temporal-spatial expression pattern for filamin C during murine embryogenesis, adult muscle regeneration and in selected myopathic models of human disease [6].
  • These results support the paradigm that the regulatory mechanisms of muscle regeneration largely recapitulate the fundamental events observed during muscle development and that filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population [6].

Anatomical context of Flnc

  • This expression pattern was further supported using RT-PCR analysis of filamin C expression in differentiating C2C12 myotubes [6].

Analytical, diagnostic and therapeutic context of Flnc


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