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Gene Review

ALOX15B  -  arachidonate 15-lipoxygenase, type B

Homo sapiens

Synonyms: 15-LOX-2, 15-LOX-B, 15-lipoxygenase 2, Arachidonate 15-lipoxygenase B, Arachidonate 15-lipoxygenase type II, ...
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Disease relevance of ALOX15B


High impact information on ALOX15B

  • The very limited current data on the role of lipoxygenase (LOX) metabolism in tumorigenesis suggests that the oxidative metabolism of linoleic and arachidonic acid possibly shifts from producing antitumorigenic 15-LOX-1 and 15-LOX-2 products to producing protumorigenic 5-LOX and 12-LOX products [1].
  • Restoring terminal differentiation and apoptosis of Caco-2 cells increased the mRNA levels of 5-LOX, 15-LOX-2, and 15-LOX-1, but the only significant increases in protein expression and enzymatic activity were of 15-LOX-1 [1].
  • These results support the hypothesis that 15-LOX-2-derived 15S-HETE may constitute an endogenous ligand for PPARgamma in the prostate and that loss of this pathway by reduced expression of 15-LOX-2 may contribute to increased proliferation and reduced differentiation in prostate carcinoma [5].
  • Immunoblot analysis with antibodies specific to 15(S)-lipoxygenase-1 (LOX-1) and 15(S)-lipoxygenase-2 (LOX-2) demonstrated the expression of 15-LOX-2, but not 15-LOX-1, in these tumor cells [6].
  • 15-Lipoxygenase 2 (15-LOX2), the most abundant arachidonate (AA)-metabolizing enzyme expressed in adult human prostate, is a negative cell-cycle regulator in normal human prostate epithelial cells [7].

Chemical compound and disease context of ALOX15B


Biological context of ALOX15B


Anatomical context of ALOX15B


Associations of ALOX15B with chemical compounds

  • Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization [7].
  • The results indicate that androgen does not directly regulate 15-LOX2 gene expression [13].
  • We identified an active steroid nuclear receptor half-site present in the 15-LOX-2 promoter fragment F-5 (-618/+177) that can interact with PPARgamma [14].
  • Soybean 15-LOX, rabbit reticulocyte 15-LOX, human 15-LOX-1, and human 15-LOX-2 oxygenate 2-AG, providing 15(S)-hydroperoxyeicosatetraenoic acid glyceryl ester [15].

Physical interactions of ALOX15B


Other interactions of ALOX15B


Analytical, diagnostic and therapeutic context of ALOX15B


  1. The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. Shureiqi, I., Wu, Y., Chen, D., Yang, X.L., Guan, B., Morris, J.S., Yang, P., Newman, R.A., Broaddus, R., Hamilton, S.R., Lynch, P., Levin, B., Fischer, S.M., Lippman, S.M. Cancer Res. (2005) [Pubmed]
  2. Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. Hsi, L.C., Wilson, L.C., Eling, T.E. J. Biol. Chem. (2002) [Pubmed]
  3. 15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa. Shappell, S.B., Keeney, D.S., Zhang, J., Page, R., Olson, S.J., Brash, A.R. J. Invest. Dermatol. (2001) [Pubmed]
  4. Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. Xu, X.C., Shappell, S.B., Liang, Z., Song, S., Menter, D., Subbarayan, V., Iyengar, S., Tang, D.G., Lippman, S.M. Neoplasia (2003) [Pubmed]
  5. 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Shappell, S.B., Gupta, R.A., Manning, S., Whitehead, R., Boeglin, W.E., Schneider, C., Case, T., Price, J., Jack, G.S., Wheeler, T.M., Matusik, R.J., Brash, A.R., Dubois, R.N. Cancer Res. (2001) [Pubmed]
  6. 15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK. Nony, P.A., Kennett, S.B., Glasgow, W.C., Olden, K., Roberts, J.D. J. Biol. Chem. (2005) [Pubmed]
  7. Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. Bhatia, B., Maldonado, C.J., Tang, S., Chandra, D., Klein, R.D., Chopra, D., Shappell, S.B., Yang, P., Newman, R.A., Tang, D.G. J. Biol. Chem. (2003) [Pubmed]
  8. 15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma. Shappell, S.B., Boeglin, W.E., Olson, S.J., Kasper, S., Brash, A.R. Am. J. Pathol. (1999) [Pubmed]
  9. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. Krieg, P., Marks, F., Fürstenberger, G. Genomics (2001) [Pubmed]
  10. Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. Subbarayan, V., Sabichi, A.L., Kim, J., Llansa, N., Logothetis, C.J., Lippman, S.M., Menter, D.G. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  11. Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. Subbarayan, V., Xu, X.C., Kim, J., Yang, P., Hoque, A., Sabichi, A.L., Llansa, N., Mendoza, G., Logothetis, C.J., Newman, R.A., Lippman, S.M., Menter, D.G. Neoplasia (2005) [Pubmed]
  12. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. Tang, S., Bhatia, B., Maldonado, C.J., Yang, P., Newman, R.A., Liu, J., Chandra, D., Traag, J., Klein, R.D., Fischer, S.M., Chopra, D., Shen, J., Zhau, H.E., Chung, L.W., Tang, D.G. J. Biol. Chem. (2002) [Pubmed]
  13. Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. Tang, S., Bhatia, B., Zhou, J., Maldonado, C.J., Chandra, D., Kim, E., Fischer, S.M., Butler, A.P., Friedman, S.L., Tang, D.G. Oncogene (2004) [Pubmed]
  14. 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. Subbarayan, V., Krieg, P., Hsi, L.C., Kim, J., Yang, P., Sabichi, A.L., Llansa, N., Mendoza, G., Logothetis, C.J., Newman, R.A., Lippman, S.M., Menter, D.G. Oncogene (2006) [Pubmed]
  15. 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. Kozak, K.R., Gupta, R.A., Moody, J.S., Ji, C., Boeglin, W.E., DuBois, R.N., Brash, A.R., Marnett, L.J. J. Biol. Chem. (2002) [Pubmed]
  16. 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation. Gonzalez, A.L., Roberts, R.L., Massion, P.P., Olson, S.J., Shyr, Y., Shappell, S.B. Hum. Pathol. (2004) [Pubmed]
  17. Detection and subcellular localization of two 15S-lipoxygenases in human cornea. Chang, M.S., Schneider, C., Roberts, R.L., Shappell, S.B., Haselton, F.R., Boeglin, W.E., Brash, A.R. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  18. Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: correlation with grade and expression in high-grade prostatic intraepithelial neoplasia. Jack, G.S., Brash, A.R., Olson, S.J., Manning, S., Coffey, C.S., Smith, J.A., Shappell, S.B. Hum. Pathol. (2000) [Pubmed]
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