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Gene Review

ALOX12B  -  arachidonate 12-lipoxygenase, 12R type

Homo sapiens

Synonyms: 12R-LOX, 12R-lipoxygenase, ARCI2, Arachidonate 12-lipoxygenase, 12R-type, Epidermis-type lipoxygenase 12
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Disease relevance of ALOX12B


High impact information on ALOX12B


Biological context of ALOX12B


Anatomical context of ALOX12B


Regulatory relationships of ALOX12B


Other interactions of ALOX12B

  • RT-PCR analysis demonstrated a predominant expression of ALOXE3, ALOX12B, and ALOX15B in skin [7].
  • ALOX15P was found on the opposite DNA strand directly adjacent to the 3'-untranslated region of ALOX12B [7].
  • We further demonstrate that the 12R-LOX/eLOX3-derived 8R-hydroxy-11R,12R-epoxide is converted by an epoxide hydrolase in COS7 cells and in human keratinocytes to a single isomer of 8,11,12-trihydroxyeicosa-5,9,14-trienoic acid [10].
  • Genetic and biochemical evidence suggests a functional link between human 12R-lipoxygenase (12R-LOX) and epidermal lipoxygenase-3 (eLOX3) in normal differentiation of the epidermis; LOX-derived fatty acid hydroperoxide is isomerized by the atypical eLOX3 into a specific epoxyalcohol that is a potential mediator in the pathway [11].

Analytical, diagnostic and therapeutic context of ALOX12B

  • A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression [6].
  • Using incubations with [(14)C]-labeled substrates and HPLC analyses, we found that the naturally occurring mutations totally eliminate the lipoxygenase activity of 12R-LOX and the hydroperoxide isomerase activity of eLOX3 [10].


  1. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. Jobard, F., Lefèvre, C., Karaduman, A., Blanchet-Bardon, C., Emre, S., Weissenbach, J., Ozgüc, M., Lathrop, M., Prud'homme, J.F., Fischer, J. Hum. Mol. Genet. (2002) [Pubmed]
  2. A novel mutation in the 12(R)-lipoxygenase (ALOX12B) gene underlies nonbullous congenital ichthyosiform erythroderma. Ashoor, G., Massé, M., García Luciano, L.M., Sheffer, R., Martinez-Mir, A., Christiano, A.M., Zlotogorski, A. Br. J. Dermatol. (2006) [Pubmed]
  3. Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis. Eckl, K.M., Krieg, P., Küster, W., Traupe, H., André, F., Wittstruck, N., Fürstenberger, G., Hennies, H.C. Hum. Mutat. (2005) [Pubmed]
  4. Lipoxygenase-catalyzed formation of R-configuration hydroperoxides. Schneider, C., Brash, A.R. Prostaglandins Other Lipid Mediat. (2002) [Pubmed]
  5. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. Yu, Z., Schneider, C., Boeglin, W.E., Marnett, L.J., Brash, A.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression. Boeglin, W.E., Kim, R.B., Brash, A.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. Krieg, P., Marks, F., Fürstenberger, G. Genomics (2001) [Pubmed]
  8. Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. F??rstenberger, G., Epp, N., Eckl, K.M., Hennies, H.C., J??rgensen, C., Hallenborg, P., Kristiansen, K., Krieg, P. Prostaglandins Other Lipid Mediat. (2007) [Pubmed]
  9. Detection and cellular localization of 12R-lipoxygenase in human tonsils. Schneider, C., Keeney, D.S., Boeglin, W.E., Brash, A.R. Arch. Biochem. Biophys. (2001) [Pubmed]
  10. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. Yu, Z., Schneider, C., Boeglin, W.E., Brash, A.R. Biochim. Biophys. Acta (2005) [Pubmed]
  11. Human and mouse eLOX3 have distinct substrate specificities: Implications for their linkage with lipoxygenases in skin. Yu, Z., Schneider, C., Boeglin, W.E., Brash, A.R. Arch. Biochem. Biophys. (2006) [Pubmed]
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