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Gene Review

Nr1h4  -  nuclear receptor subfamily 1, group H,...

Rattus norvegicus

Synonyms: Bar, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Fxr, ...
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High impact information on Nr1h4


Associations of Nr1h4 with chemical compounds


Analytical, diagnostic and therapeutic context of Nr1h4

  • Activities of beta-glucocerebrosidase and steroid sulfatase, enzymes previously linked to barrier maturation, also increased after treatment with PPARalpha and FXR activators [1].


  1. Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. Hanley, K., Jiang, Y., Crumrine, D., Bass, N.M., Appel, R., Elias, P.M., Williams, M.L., Feingold, K.R. J. Clin. Invest. (1997) [Pubmed]
  2. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. Hanley, K., Kömüves, L.G., Bass, N.M., He, S.S., Jiang, Y., Crumrine, D., Appel, R., Friedman, M., Bettencourt, J., Min, K., Elias, P.M., Williams, M.L., Feingold, K.R. J. Invest. Dermatol. (1999) [Pubmed]
  3. Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. Kömüves, L.G., Hanley, K., Jiang, Y., Elias, P.M., Williams, M.L., Feingold, K.R. J. Invest. Dermatol. (1998) [Pubmed]
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