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Chemical Compound Review

JH-III     methyl(2E,6E)-9-(3,3- dimethyloxiran-2-yl)...

Synonyms: AC1NSPFY, NSC-688246, MEGxp0_001814, AC1Q5YYM, NSC688246, ...
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High impact information on juvenile hormone III


Biological context of juvenile hormone III

  • This has led to the identification of endothelial cells in the anterior midgut as the site of synthesis and to the concept that de novo pheromone biosynthesis is regulated in part by the positive effect of juvenile hormone III (JHIII) on gene expression for HMG-R [5].
  • As the mevalonate pathway and its regulation have been studied in few other insects, broader issues addressed through the study of scolytid pheromone biosynthesis include major step versus coordinate regulation of the pathway and a genomics approach to elucidating the entire pathway and the mode of action of JHIII [5].
  • Juvenile hormone III binding sites were located in the nuclear, microsomal and post-microsomal supernatant fractions of the follicle cells of Tenebrio molitor [6].
  • Although both methyl farnesoate (MF) and juvenile hormone III also caused up-regulation of the CfVg gene, their effects are only significant at much higher concentrations [7].
  • Synthesis of both optical isomers of insect juvenile hormone III and their affinity for the juvenile hormone-specific binding protein of Manduca sexta [8].

Anatomical context of juvenile hormone III


Associations of juvenile hormone III with other chemical compounds


Gene context of juvenile hormone III


Analytical, diagnostic and therapeutic context of juvenile hormone III

  • Juvenile hormone III could not be excluded as a product of the corpora allata owing to the low cross reactivity of this homolog (1.7%) in the radioimmunoassay [23].
  • Application of JHIII to the surface of both prothoracic hemiganglia, accompanied by microinjection of emetine into one hemiganglion resulted in the female emetine into one hemiganglion resulted in the female circling phonotactically toward the side receiving emetine injection, with a 25 to 35 dB drop in threshold (Fig. 6) [24].
  • The results of HPLC analysis indicated the presence of juvenile hormone III together with juvenile hormones I and II in parasitized eggs, but only juvenile hormones I and II in nonparasitized eggs [25].
  • We have compared gene expression, using the Differential Display Reverse Transcriptase-Polymerase Chain Reaction (DDRT-PCR) technique, by means of mRNA profile in Melipona scutellaris during ontogenetic postembryonic development, in adult worker, and in both Natural and Juvenile Hormone III-induced adult queen [26].


  1. Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. Hanley, K., Jiang, Y., Crumrine, D., Bass, N.M., Appel, R., Elias, P.M., Williams, M.L., Feingold, K.R. J. Clin. Invest. (1997) [Pubmed]
  2. CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata. Helvig, C., Koener, J.F., Unnithan, G.C., Feyereisen, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Mating experience and juvenile hormone enhance sexual signaling and mating in male Caribbean fruit flies. Teal, P.E., Gomez-Simuta, Y., Proveaux, A.T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. A family of neuropeptides that inhibit juvenile hormone biosynthesis in the cricket, Gryllus bimaculatus. Lorenz, M.W., Kellner, R., Hoffmann, K.H. J. Biol. Chem. (1995) [Pubmed]
  5. Biochemistry and molecular biology of de novo isoprenoid pheromone production in the Scolytidae. Seybold, S.J., Tittiger, C. Annu. Rev. Entomol. (2003) [Pubmed]
  6. Hymenolepis diminuta-induced fecundity reduction may be caused by changes in hormone binding to Tenebrio molitor ovaries. Webb, T.J., Hurd, H. Parasitology (1995) [Pubmed]
  7. Vitellogenesis in the red crab Charybdis feriatus: Hepatopancreas-specific expression and farnesoic acid stimulation of vitellogenin gene expression. Mak, A.S., Choi, C.L., Tiu, S.H., Hui, J.H., He, J.G., Tobe, S.S., Chan, S.M. Mol. Reprod. Dev. (2005) [Pubmed]
  8. Synthesis of both optical isomers of insect juvenile hormone III and their affinity for the juvenile hormone-specific binding protein of Manduca sexta. Schooley, D.A., Bergot, B.J. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
  9. A Drosophila melanogaster mutant resistant to a chemical analog of juvenile hormone. Wilson, T.G., Fabian, J. Dev. Biol. (1986) [Pubmed]
  10. Differential expression of two RXR/ultraspiracle isoforms during the life cycle of the hemimetabolous insect Blattella germanica (Dictyoptera, Blattellidae). Maestro, O., Cruz, J., Pascual, N., Martín, D., Bellés, X. Mol. Cell. Endocrinol. (2005) [Pubmed]
  11. Tissue localization and regulation by juvenile hormone of human allergen Bla g 4 from the German cockroach, Blattella germanica (L.). Fan, Y., Gore, J.C., Redding, K.O., Vailes, L.D., Chapman, M.D., Schal, C. Insect Mol. Biol. (2005) [Pubmed]
  12. Parasite manipulation of insect reproduction: who benefits? Hurd, H. Parasitology (1998) [Pubmed]
  13. Effects of juvenile hormone on eggs and adults of the cat flea (Siphonaptera: Pulicidae). Meola, R.W., Dean, S.R., Bhaskaran, G. J. Med. Entomol. (2001) [Pubmed]
  14. Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. Kömüves, L.G., Hanley, K., Jiang, Y., Elias, P.M., Williams, M.L., Feingold, K.R. J. Invest. Dermatol. (1998) [Pubmed]
  15. Activity of juvenile hormone and juvenile hormone analogues on the growth of Trypanosoma cruzi. Stoka, A.M. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  16. Characterization and regulation of HMG-CoA reductase during a cycle of juvenile hormone synthesis. Feyereisen, R., Farnsworth, D.E. Mol. Cell. Endocrinol. (1987) [Pubmed]
  17. Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. Neuhüser, T., Sorge, D., Stay, B., Hoffmann, K.H. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (1994) [Pubmed]
  18. Juvenile hormone agonists affect the occurrence of male Daphnia. Tatarazako, N., Oda, S., Watanabe, H., Morita, M., Iguchi, T. Chemosphere (2003) [Pubmed]
  19. Juvenile hormone III-dependent conformational changes of the nuclear receptor ultraspiracle. Jones, G., Wozniak, M., Chu, Y., Dhar, S., Jones, D. Insect Biochem. Mol. Biol. (2001) [Pubmed]
  20. In vitro metabolism of juvenile hormone III and juvenile hormone III bisepoxide by Drosophila melanogaster and mammalian cytosolic epoxide hydrolase. Casas, J., Harshman, L.G., Messeguer, A., Kuwano, E., Hammock, B.D. Arch. Biochem. Biophys. (1991) [Pubmed]
  21. Purification and kinetic characterisation of juvenile hormone esterase from Drosophila melanogaster. Campbell, P.M., Oakeshott, J.G., Healy, M.J. Insect Biochem. Mol. Biol. (1998) [Pubmed]
  22. A simplified method for synthesizing juvenile hormone-protein conjugates. Goodman, W.G. J. Lipid Res. (1990) [Pubmed]
  23. In vitro biosynthesis of juvenile hormone by the larval corpora allata of Manduca sexta: quantificationby radioimmunoassay. Granger, N.A., Bollenbacher, W.E., Vince, R., Gilbert, L.I., Baehr, J.C., Dray, F. Mol. Cell. Endocrinol. (1979) [Pubmed]
  24. Regulation of cricket phonotaxis through hormonal control of the threshold of an identified auditory neuron. Stout, J., Atkins, G., Zacharias, D. J. Comp. Physiol. A (1991) [Pubmed]
  25. Endocrine interrelationship between the parasitoid Chelonus sp. and its host Trichoplusia ni. Grossniklaus-Bürgin, C., Lanzrein, B. Arch. Insect Biochem. Physiol. (1990) [Pubmed]
  26. Differentially displayed expressed sequence tags in Melipona scutellaris (Hymenoptera, Apidae, Meliponini) development. Santana, F.A., Nunes, F.M., Vieira, C.U., Machado, M.A., Kerr, W.E., Silva, W.A., Bonetti, A.M. An. Acad. Bras. Cienc. (2006) [Pubmed]
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