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Gene Review

Birc2  -  baculoviral IAP repeat-containing 2

Rattus norvegicus

Synonyms: Api2, rIAP1
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Disease relevance of Birc2

  • As rIAPP cannot form amyloid fibers, our results show that fiber formation need not be directly coupled to toxicity [1].

High impact information on Birc2

  • Here, we report that rIAPP is capable of permeabilizing membranes under conditions that permit rIAPP membrane binding [1].
  • Western blotting revealed that nearly all of the rIAP in the jejunum extracts was rIAP-I, whereas in duodenum the percentage of rIAP-I (55%) correlated with the degree of AP activation (60% relative to that seen with jejunal extracts) [2].


  1. Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. Knight, J.D., Hebda, J.A., Miranker, A.D. Biochemistry (2006) [Pubmed]
  2. Characterization of structural and catalytic differences in rat intestinal alkaline phosphatase isozymes. Harada, T., Koyama, I., Matsunaga, T., Kikuno, A., Kasahara, T., Hassimoto, M., Alpers, D.H., Komoda, T. FEBS J. (2005) [Pubmed]
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