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Gene Review

Birc2  -  baculoviral IAP repeat-containing 2

Mus musculus

Synonyms: AW146227, Api1, Api2, Baculoviral IAP repeat-containing protein 2, Birc3, ...
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Disease relevance of Birc2


High impact information on Birc2


Biological context of Birc2

  • Our results demonstrate that overexpression of IAP-2 renders the heart more resistant to apoptosis and I/R injury [1].
  • To test whether IAP-2 prevents cardiac apoptosis and injury following ischemia/reperfusion, we generated a line of transgenic mice that carried a mouse IAP-2 transgene [1].
  • In conclusion, in this study we have cloned the full-length cDNA of rat IAP2, and for the first time we have isolated and analysed promoter sequences of this gene, leading to the identification of enhancer elements [2].
  • Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis [5].

Anatomical context of Birc2


  1. Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice. Chua, C.C., Gao, J., Ho, Y.S., Xiong, Y., Xu, X., Chen, Z., Hamdy, R.C., Chua, B.H. Biochim. Biophys. Acta (2007) [Pubmed]
  2. Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M.A., Denton, M., Gu, S., Li, S., Qiang, M. Biochem. J. (2002) [Pubmed]
  3. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Zender, L., Spector, M.S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.T., Luk, J.M., Wigler, M., Hannon, G.J., Mu, D., Lucito, R., Powers, S., Lowe, S.W. Cell (2006) [Pubmed]
  4. Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L. Husain, Z., Holodick, N., Day, C., Szymanski, I., Alper, C.A. J. Clin. Immunol. (2006) [Pubmed]
  5. Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis. Shafey, D., Korneluk, R., Holcik, M. Apoptosis (2006) [Pubmed]
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