Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Birc2 - baculoviral IAP repeat-containing 2

Mus musculus

Synonyms: AW146227, Api1, Api2, Baculoviral IAP repeat-containing protein 2, Birc3, ...

Chua, C.C. et al., Dong, Z. et al., Zender, L. et al., Husain, Z. et al., Shafey, D. et al.

Dong, Nishiyama, Yi, Venkatachalam, Denton, Gu, Li, Qiang,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Birc2

During ischemia, IAP-2 is upregulated dramatically, while the other IAPs show little or no change [1].
Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice [1].
We showed recently the activation of IAP2 transcription by severe hypoxia [2].

High impact information on Birc2

Gene-expression analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon [3].
Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia [2].
To pursue this regulation, we have cloned the full-length cDNA of rat IAP2, and have isolated and analysed the promoter regions of this gene [2].
Finally, the IAP2 gene promoter was activated significantly by severe hypoxia and not by CoCl(2) or desferrioxamine, pharmacological inducers of hypoxia-inducible factor-1 [2].
Upregulation of the IAP-2 gene protects B cells from deletion and allows for IgA secretion in this system [4].

Biological context of Birc2

Our results demonstrate that overexpression of IAP-2 renders the heart more resistant to apoptosis and I/R injury [1].
To test whether IAP-2 prevents cardiac apoptosis and injury following ischemia/reperfusion, we generated a line of transgenic mice that carried a mouse IAP-2 transgene [1].
In conclusion, in this study we have cloned the full-length cDNA of rat IAP2, and for the first time we have isolated and analysed promoter sequences of this gene, leading to the identification of enhancer elements [2].
Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis [5].

Anatomical context of Birc2

Immunohistochemical studies revealed more intense staining of IAP-2 in the myocytes of transgenic mouse hearts [1].
To assess the role of IAP-2 in I/R injury, the transgenic mice were subjected to ligation of the left descending anterior coronary artery ligation followed by reperfusion [1].

References

Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice. Chua, C.C., Gao, J., Ho, Y.S., Xiong, Y., Xu, X., Chen, Z., Hamdy, R.C., Chua, B.H. Biochim. Biophys. Acta (2007) [Pubmed]
Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M.A., Denton, M., Gu, S., Li, S., Qiang, M. Biochem. J. (2002) [Pubmed]
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Zender, L., Spector, M.S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.T., Luk, J.M., Wigler, M., Hannon, G.J., Mu, D., Lucito, R., Powers, S., Lowe, S.W. Cell (2006) [Pubmed]
Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L. Husain, Z., Holodick, N., Day, C., Szymanski, I., Alper, C.A. J. Clin. Immunol. (2006) [Pubmed]
Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis. Shafey, D., Korneluk, R., Holcik, M. Apoptosis (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

BIRC2	Bos taurus
BIRC2	Canis lupus familiaris
birc2	Danio rerio
Iap2	Drosophila melanogaster
BIRC2	Gallus gallus
BIRC2	Homo sapiens
BIRC2	Macaca mulatta
BIRC2	Pan troglodytes
Birc2	Rattus norvegicus
birc2	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.