Gene Review:
Iap2 - Inhibitor of apoptosis 2
Drosophila melanogaster
Synonyms:
Apoptosis 2 inhibitor, CG8293, D-IAP2, D-iap2, DIAP, ...
- The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. Huh, J.R., Foe, I., Muro, I., Chen, C.H., Seol, J.H., Yoo, S.J., Guo, M., Park, J.M., Hay, B.A. J. Biol. Chem. (2007)
- The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection. Leulier, F., Lhocine, N., Lemaitre, B., Meier, P. Mol. Cell. Biol. (2006)
- Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines. Mizukawa, K., Kawamura, A., Sasayama, T., Tanaka, K., Kamei, M., Sasaki, M., Kohmura, E. J. Neurooncol. (2006)
- A mutational analysis of the baculovirus inhibitor of apoptosis Op-IAP. Vucic, D., Kaiser, W.J., Miller, L.K. J. Biol. Chem. (1998)
- Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. Martin, S.J. Cell (2002)
- Structural basis of IAP recognition by Smac/DIABLO. Wu, G., Chai, J., Suber, T.L., Wu, J.W., Du, C., Wang, X., Shi, Y. Nature (2000)
- A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Jiang, C., Lamblin, A.F., Steller, H., Thummel, C.S. Mol. Cell (2000)
- Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. Kleino, A., Valanne, S., Ulvila, J., Kallio, J., Myllymäki, H., Enwald, H., Stöven, S., Poidevin, M., Ueda, R., Hultmark, D., Lemaitre, B., Rämet, M. EMBO J. (2005)
- Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes. Wing, J.P., Zhou, L., Schwartz, L.M., Nambu, J.R. Cell Death Differ. (1998)
- Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Martins, L.M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G.P., Creasy, C.L., Martin, A., Hargreaves, I., Heales, S.J., Okada, H., Brandner, S., Schulz, J.B., Mak, T., Downward, J. Mol. Cell. Biol. (2004)
- An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. Gesellchen, V., Kuttenkeuler, D., Steckel, M., Pelte, N., Boutros, M. EMBO Rep. (2005)
- Anti- and pro-apoptotic activities of baculovirus and Drosophila IAPs in an insect cell line. Harvey, A.J., Soliman, H., Kaiser, W.J., Miller, L.K. Cell Death Differ. (1997)
- Steroid regulated programmed cell death during Drosophila metamorphosis. Jiang, C., Baehrecke, E.H., Thummel, C.S. Development (1997)
- The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. Muro, I., Hay, B.A., Clem, R.J. J. Biol. Chem. (2002)
- A highly conserved arginine is critical for the functional folding of inhibitor of apoptosis (IAP) BIR domains. Luque, L.E., Grape, K.P., Junker, M. Biochemistry (2002)
- Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. de Velasco, B., Erclik, T., Shy, D., Sclafani, J., Lipshitz, H., McInnes, R., Hartenstein, V. Dev. Biol. (2007)
- Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line. Vucic, D., Seshagiri, S., Miller, L.K. Mol. Cell. Biol. (1997)
- Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Herman-Bachinsky, Y., Ryoo, H.D., Ciechanover, A., Gonen, H. Cell Death Differ. (2007)
- STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Doumanis, J., Quinn, L., Richardson, H., Kumar, S. Cell Death Differ. (2001)
- Interaction of Drosophila inhibitors of apoptosis with thick veins, a type I serine/threonine kinase receptor for decapentaplegic. Oeda, E., Oka, Y., Miyazono, K., Kawabata, M. J. Biol. Chem. (1998)
- Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. Goyal, L., McCall, K., Agapite, J., Hartwieg, E., Steller, H. EMBO J. (2000)
- Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: Expression, cellular localization, and phylogeny. Riehle, M.A., Fan, Y., Cao, C., Brown, M.R. Peptides (2006)