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Gene Review

Fgf16  -  fibroblast growth factor 16

Rattus norvegicus

Synonyms: FGF-16, Fibroblast growth factor 16
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High impact information on Fgf16

  • Inhibition of its secretion by brefeldin A and identification of an N-glycan on the secreted form confirmed that FGF-16 is secreted by means of the endoplasmic reticulum and Golgi apparatus, as are secreted proteins having a conventional cleavable signal sequence [1].
  • When chimerized with prolactin, however, the N-terminal sequence of FGF-16 was not able to mediate secretion of the chimera [1].
  • Point mutations that made the N terminus less hydrophobic had little effect on secretion of FGF-16, whereas making the central hydrophobic region less hydrophobic abolished secretion [1].
  • We also examined the mitogenic activity of recombinant rat FGF-16 for primary brown adipocytes prepared from rat embryonic brown adipose tissue [2].
  • As a great induction of proliferation of rat brown adipose tissue during cold acclimation was reported, we also examined the expression of FGF-16 mRNA in the brown adipose tissue during cold acclimation by Northern blotting analysis [2].

Anatomical context of Fgf16


  1. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. Miyakawa, K., Imamura, T. J. Biol. Chem. (2003) [Pubmed]
  2. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. Konishi, M., Mikami, T., Yamasaki, M., Miyake, A., Itoh, N. J. Biol. Chem. (2000) [Pubmed]
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