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Gene Review

RPL39  -  ribosomal protein L39

Homo sapiens

Synonyms: 60S ribosomal protein L39, L39, RPL39P42, RPL39_23_1806
 
 
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High impact information on RPL39

  • As suggested by unaltered transcript stabilities during hyphal induction, this regulation occurs on the transcriptional level; a conserved 18 bp palindromic sequence (5'-TTAGGGCTATAGCCCTAA-3'), which is present in the promoter regions of the RPL39 and RPS7 genes, may be involved in regulation [1].
  • A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells [2].
  • A cDNA clone encoding a human ribosomal protein L39 (hRPL39) was isolated through a random cDNA sequencing approach to a cDNA library constructed from a human colon carcinoma cell line of COLO 205 [3].
  • Although levels of hRPL39 mRNA were different in several cell lines including carcinoma cell lines from different tissues, they were shown not to be cell cycle-dependent in a human fibroblast cell line of TIG-1 [3].
 

Analytical, diagnostic and therapeutic context of RPL39

References

  1. Characterization and regulation of the genes encoding ribosomal proteins L39 and S7 of the human pathogen Candida albicans. Delbrück, S., Sonneborn, A., Gerads, M., Grablowitz, A.H., Ernst, J.F. Yeast (1997) [Pubmed]
  2. A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. Nadano, D., Notsu, T., Matsuda, T., Sato, T. Biochim. Biophys. Acta (2002) [Pubmed]
  3. Molecular cloning of a cDNA encoding human ribosomal protein L39. Otsuka, S., Tanaka, M., Saito, S., Yoshimoto, K., Itakura, M. Biochim. Biophys. Acta (1996) [Pubmed]
 
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