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Gene Review

MED15  -  mediator complex subunit 15

Homo sapiens

Synonyms: ARC105, Activator-recruited cofactor 105 kDa component, Arc105, CAG7A, CTG repeat protein 7a, ...
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Disease relevance of PCQAP


High impact information on PCQAP


Chemical compound and disease context of PCQAP


Biological context of PCQAP

  • Recently, DeLuca and colleagues reported that polymorphisms in a trinucleotide repeat in exon 7 of PCQAP were associated with schizophrenia in a case-control study of Italian schizophrenics [9].
  • The predicted open reading frame also contains a consensus bipartite nuclear localization signal, though no specific DNA-binding domain is found.The corresponding TIG-1 mRNA is ubiquitously expressed [8].
  • Cotransfection assays of K562 cells, using a GAL4-TIG-1 fusion gene and GAL4 operator-CAT, indicate that the TIG-1 protein may have transcriptional regulatory activity when tethered to DNA [8].
  • Tazarotene-induced gene-1 (Tig1) and CCAAT/enhancer binding protein-alpha (C/ebpalpha) were chosen for further study [10].
  • A transient transfection assay demonstrated that the overexpression of cyclin D1 inhibited DNA synthesis of TIG-1 cells [4].

Anatomical context of PCQAP


Associations of PCQAP with chemical compounds

  • Amtolmetin guacyl (MED15) is a new non-steroidal anti-inflammatory drug (NSAID) which shares anti-inflammatory, analgesic and antipyretic activity with the other drugs of the NSAID family but which shows, unexpectedly, strong gastroprotective activity similar to misoprostol [3].
  • The MED15 enteroprotective effect is related to stimulation of intestinal capsaicin receptors as demonstrated by the loss of protective effect in the presence of capsazepine, a specific receptor antagonist of capsaicin [3].
  • Further, the incorporation of apigenin, 3-hydroxyflavone, luteolin, and quercetin, which are more toxic, into TIG-1 cells during 24-h incubation was examined [13].
  • Using 2',7'-dichlorofluorescin diacetate (DCF-DA), the intracellular reactive oxygen species (ROS) level of flavonoid-treated TIG-1 cells was examined [13].

Physical interactions of PCQAP

  • TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system [7].
  • In a recent letter, Yang et al. present a comprehensive series of experiments, spanning a wide range of disciplines, that identify ARC105 as a component of the ARC complex that interacts directly with SREBP and is necessary for SREBP function () [14].

Other interactions of PCQAP

  • PCQAP encodes for a subunit of the large multiprotein complex PC2, which exhibits a coactivator function in RNA polymerase II mediated transcription [15].
  • Co-expression of TRIM11 increased ARC105 degradation but a proteasome inhibitor suppressed this [7].
  • Although levels of hRPL39 mRNA were different in several cell lines including carcinoma cell lines from different tissues, they were shown not to be cell cycle-dependent in a human fibroblast cell line of TIG-1 [16].


  1. Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. Jing, C., El-Ghany, M.A., Beesley, C., Foster, C.S., Rudland, P.S., Smith, P., Ke, Y. J. Natl. Cancer Inst. (2002) [Pubmed]
  2. Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene. Zhang, J., Liu, L., Pfeifer, G.P. Oncogene (2004) [Pubmed]
  3. Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. Tubaro, E., Belogi, L., Mezzadri, C.M., Bettelli, E. Eur. J. Pharmacol. (2003) [Pubmed]
  4. Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2. Fukami-Kobayashi, J., Mitsui, Y. Exp. Cell Res. (1999) [Pubmed]
  5. Progress of aging in human diploid cells transformed with a tsA mutant of simian virus 40. Ide, T., Tsuji, Y., Nakashima, T., Ishibashi, S. Exp. Cell Res. (1984) [Pubmed]
  6. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. Nagpal, S., Patel, S., Asano, A.T., Johnson, A.T., Duvic, M., Chandraratna, R.A. J. Invest. Dermatol. (1996) [Pubmed]
  7. TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. Ishikawa, H., Tachikawa, H., Miura, Y., Takahashi, N. FEBS Lett. (2006) [Pubmed]
  8. A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues. Abraham, S., Solomon, W.B. Gene (2000) [Pubmed]
  9. An association study of PCQAP polymorphisms and schizophrenia. Sandhu, H.K., Hollenbeck, N., Wassink, T.H., Philibert, R.A. Psychiatr. Genet. (2004) [Pubmed]
  10. Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Takai, N., Kawamata, N., Walsh, C.S., Gery, S., Desmond, J.C., Whittaker, S., Said, J.W., Popoviciu, L.M., Jones, P.A., Miyakawa, I., Koeffler, H.P. Mol. Cancer Res. (2005) [Pubmed]
  11. Correlation between the presence of T-antigen and the reinitiation of host DNA synthesis in senescent human diploid fibroblasts after SV40 infection. Tsuji, Y., Ide, T., Ishibashi, S. Exp. Cell Res. (1983) [Pubmed]
  12. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., Mimura, A. Cancer Lett. (2007) [Pubmed]
  13. Cytotoxicity of flavonoids toward cultured normal human cells. Matsuo, M., Sasaki, N., Saga, K., Kaneko, T. Biol. Pharm. Bull. (2005) [Pubmed]
  14. An ARC light on lipid metabolism. Rawson, R.B. Cell metabolism. (2006) [Pubmed]
  15. Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. De Luca, A., Conti, E., Grifone, N., Amati, F., Spalletta, G., Caltagirone, C., Bonaviri, G., Pasini, A., Gennarelli, M., Stefano, B., Berti, L., Mittler, G., Meisterernst, M., Dallapiccola, B., Novelli, G. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003) [Pubmed]
  16. Molecular cloning of a cDNA encoding human ribosomal protein L39. Otsuka, S., Tanaka, M., Saito, S., Yoshimoto, K., Itakura, M. Biochim. Biophys. Acta (1996) [Pubmed]
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