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Gene Review

CHP2  -  calcineurin-like EF-hand protein 2

Homo sapiens

Synonyms: Calcineurin B homologous protein 2, HCA520, Hepatocellular carcinoma-associated antigen 520
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Disease relevance of LOC63928


High impact information on LOC63928

  • We show that the cytoplasmic alpha-helix of NHE1 is inserted into the hydrophobic cleft formed by N- and C-lobes of CHP2 and that the size and shape of this crevice together with hydrogen bond formation at multiple positions assure a high degree of specificity for interaction with NHE members [3].
  • In this study, we characterized the function of another isoform of CHP (designated CHP2) that has a 61% amino acid identity with CHP1 [4].
  • Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger [4].
  • The Chp2 genome is 4,567 bp and encodes up to eight open reading frames (ORFs); it is similar in overall organization to the Chp1 genome [2].
  • Chp2 double-stranded circular replicative-form DNA was purified and used as a template for DNA sequence analysis [2].

Biological context of LOC63928

  • They exhibit tight temperature-dependent growth, in the presence and absence of serum, with cell division at 33 C and growth inhibition at 39 C. CHP2 cells, at both temperatures, showed diffuse immunostaining for human alpha-subunit and focal staining for TSH beta [5].

Physical interactions of LOC63928

  • We propose that serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells [4].

Regulatory relationships of LOC63928

  • Serum (10%) induced a significant cytoplasmic alkalinization (0.1-0.2 pH unit) in cells co-expressing CHP1 and NHE1 but not in cells co-expressing CHP2 and NHE1 [4].

Other interactions of LOC63928

  • These properties of CHP2/NHE1 cells are similar to those of malignantly transformed cells [4].


  1. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. Wang, Y., Han, K.J., Pang, X.W., Vaughan, H.A., Qu, W., Dong, X.Y., Peng, J.R., Zhao, H.T., Rui, J.A., Leng, X.S., Cebon, J., Burgess, A.W., Chen, W.F. J. Immunol. (2002) [Pubmed]
  2. Molecular characterization of a bacteriophage (Chp2) from Chlamydia psittaci. Liu, B.L., Everson, J.S., Fane, B., Giannikopoulou, P., Vretou, E., Lambden, P.R., Clarke, I.N. J. Virol. (2000) [Pubmed]
  3. Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. Ammar, Y.B., Takeda, S., Hisamitsu, T., Mori, H., Wakabayashi, S. EMBO J. (2006) [Pubmed]
  4. Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. Pang, T., Wakabayashi, S., Shigekawa, M. J. Biol. Chem. (2002) [Pubmed]
  5. Immortalized human pituitary cells express glycoprotein alpha-subunit and thyrotropin beta (TSH beta). Ham, J., Webster, J., Bond, J.A., Jasani, B., Lewis, M.D., Hepburn, P.J., Davies, J.S., Lewis, B.M., Thomas, D.W., Scanlon, M.F. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
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