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Gene Review:

Chp2 - calcineurin-like EF hand protein 2

Mus musculus

Synonyms: 2010110P09Rik, Calcineurin B homologous protein 2, Cbhp2, Hca520, Hepatocellular carcinoma-associated antigen 520 homolog

Everson, J.S. et al.

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Disease relevance of 2010110P09Rik

Chp2 can infect C. abortus, C. felis, and C. pecorum but is unable to infect other members of this genus, including C. caviae and C. pneumoniae, despite the fact that these chlamydial species support the replication of very closely related bacteriophages [1].
In this work we investigated the biological properties and host range of the recently described bacteriophage Chp2 that was originally discovered in Chlamydophila abortus [1].
Chp2 does not infect members of the genus Chlamydia (C. trachomatis, C. suis, or C. muridarum) [1].

High impact information on 2010110P09Rik

Biological properties and cell tropism of Chp2, a bacteriophage of the obligate intracellular bacterium Chlamydophila abortus [1].
Monoclonal antibodies 40 and 55 also detected bacteriophage Chp2 antigens in chlamydia-infected eukaryotic cells [1].
Thus, we prepared hybridomas secreting monoclonal antibodies (monoclonal antibodies 40 and 55) that were specific for Chp2 [1].

Analytical, diagnostic and therapeutic context of 2010110P09Rik

We demonstrated that Chp2 binds both C. abortus elementary bodies and reticulate bodies in an enzyme-linked immunosorbent assay [1].

References

Biological properties and cell tropism of Chp2, a bacteriophage of the obligate intracellular bacterium Chlamydophila abortus. Everson, J.S., Garner, S.A., Fane, B., Liu, B.L., Lambden, P.R., Clarke, I.N. J. Bacteriol. (2002) [Pubmed]

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CHP2	Bos taurus
pbo-1	Caenorhabditis elegans
chp2	Danio rerio
CHP2	Homo sapiens
CHP2	Macaca mulatta
CHP2	Pan troglodytes
Chp2	Rattus norvegicus

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