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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OXCT2  -  3-oxoacid CoA transferase 2

Homo sapiens

Synonyms: 3-oxoacid CoA-transferase 2A, FKSG25, FLJ00030, SCOT-T, SCOT-t, ...
 
 
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High impact information on OXCT2

  • Thus, we termed this gene scot-t (testis-specific succinyl CoA:3-oxo acid CoA transferase) [1].
  • The results suggest that the scot-t protein plays important roles in the energy metabolism of spermatozoa [1].
  • The scot-t protein was detected first in elongated spermatids at step 8 or 9 as faint signals and gradually accumulated during spermiogenesis [1].
  • In conclusion, we have demonstrated that h-Scot-t is a single intronless gene specifically expressed in the testis [2].
  • The entire coding region of the mRNA and the deduced amino acid sequence of human Scot-t (h-Scot-t) showed 75.4 and 75.8% identity with mouse scot-t respectively [2].
 

Biological context of OXCT2

  • Previously, we have cloned a testis-specific succinyl CoA: 3-oxo acid CoA transferase (scot-t) cDNA from a subtracted cDNA library of mouse testis and demonstrated its expression to be specific to late haploid male germ cells [2].
  • We showed that the h-Scot-t gene was intronless by using a polymerase chain reaction technique and that a non-functional pseudogene, 98% similar to h-Scot-t, was also located on the human genome (1p33-34.3) [2].
 

Associations of OXCT2 with chemical compounds

  • Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA [2].

References

  1. Isolation and characterization of a haploid germ cell-specific novel complementary deoxyribonucleic acid; testis-specific homologue of succinyl CoA:3-Oxo acid CoA transferase. Koga, M., Tanaka, H., Yomogida, K., Nozaki, M., Tsuchida, J., Ohta, H., Nakamura, Y., Masai, K., Yoshimura, Y., Yamanaka, M., Iguchi, N., Nojima, H., Matsumiya, K., Okuyama, A., Nishimune, Y. Biol. Reprod. (2000) [Pubmed]
  2. Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA. Tanaka, H., Kohroki, J., Iguchi, N., Onishi, M., Nishimune, Y. Mol. Hum. Reprod. (2002) [Pubmed]
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