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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NOM1  -  nucleolar protein with MIF4G domain 1

Homo sapiens

Synonyms: C7orf3, Nucleolar MIF4G domain-containing protein 1, PPP1R113, SGD1, SGD1 homolog
 
 
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Disease relevance of NOM1

  • Our previous study showed that human peritoneal conditioned medium (CM) increased the matrix metalloproteinase-9 (MMP-9) secretion and invasiveness of ovarian cancer cells (NOM1) [1].
 

High impact information on NOM1

  • Furthermore, after immunoprecipitation by antifibronectin antibody supernatant of the peritoneal CM did not increase MMP-9 activity in NOM1 cells [1].
  • Invasiveness of NOM1 cells was enhanced by fibronectin and the peritoneal CM in a concentration-dependent manner, and anti-integrin alpha5/FnR antibody blocked these effects [1].
  • Database searches reveal that NOM1 homologs exist in several organisms and that at least two of these are essential genes [2].
  • NOM1, which includes a previously described EST called c7orf3, encodes a ubiquitously expressed transcript composed of 11 exons and an approximately 3 kb 3' UTR that contains several Alu repeats [2].
  • Moreover, we found that both the MEK1 inhibitor and the P13-K inhibitor, but not the PKC inhibitor, strongly suppressed the invasiveness of NOM1 cells [3].
 

Anatomical context of NOM1

  • To investigate the influence of normal tissues on secretion of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) by ovarian cancer cells, conditioned medium of several normal human tissues (peritoneum, myometrium, and ovary) was added to ovarian cancer cells (NOM1) [4].
 

Other interactions of NOM1

  • An increase of MMP-9 activity in NOM1 cell CM by the peritoneal CM was almost completely blocked by 20 microg/ml of anti-integrin alpha5/FnR antibody and RGD polypeptides [1].
  • Addition of conditioned medium from these normal tissues to NOM1 cells increased the levels of MMPs and TIMP-1 in NOM1 conditioned medium [4].

References

  1. Fibronectin secretion from human peritoneal tissue induces Mr 92,000 type IV collagenase expression and invasion in ovarian cancer cell lines. Shibata, K., Kikkawa, F., Nawa, A., Suganuma, N., Hamaguchi, M. Cancer Res. (1997) [Pubmed]
  2. Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. Simmons, H.M., Ruis, B.L., Kapoor, M., Hudacek, A.W., Conklin, K.F. Gene (2005) [Pubmed]
  3. Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells. Thant, A.A., Nawa, A., Kikkawa, F., Ichigotani, Y., Zhang, Y., Sein, T.T., Amin, A.R., Hamaguchi, M. Clin. Exp. Metastasis (2000) [Pubmed]
  4. The different stimulatory effect of normal tissues on the secretion of matrix metalloproteinases and their inhibitors by human ovarian cancer cells. Kikkawa, F., Nawa, A., Shibata, K., Obata, N.H., Tamakoshi, K., Suzuki, S., Mizutani, S. Anticancer Res. (1998) [Pubmed]
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