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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TPSB2  -  tryptase beta 2 (gene/pseudogene)

Homo sapiens

Synonyms: TPS2, Tryptase II, Tryptase beta-2, Tryptase-2, tryptaseB, ...
 
 
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High impact information on TPSB2

  • We found that both TPS1 and TPS2 are required for high-temperature (37 degrees C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of T6P, which makes this enzyme a fungicidal target [1].
  • Sorbitol suppresses the growth defect in the tps1 and tps2 mutants at 37 degrees C, which supports the hypothesis that these sugars (trehalose and sorbitol) act primarily as stress protectants for proteins and membranes during exposure to high temperatures in C. neoformans [1].
  • We also compared the type, frequency and distribution of single nucleotide polymorphisms in TPS1 and TPS2 and we observed that the polymorphism frequency within these two loci is unexpectedly high (approximately 1 SNP every 90 bp) and that some of the allele frequencies differ significantly among the three ethnic groups [2].
  • Tryptase (TPSB2) was expressed at the highest level among all transcripts and its expression level reached a plateau at 8 weeks [3].

References

  1. Characterization and Regulation of the Trehalose Synthesis Pathway and Its Importance in the Pathogenicity of Cryptococcus neoformans. Petzold, E.W., Himmelreich, U., Mylonakis, E., Rude, T., Toffaletti, D., Cox, G.M., Miller, J.L., Perfect, J.R. Infect. Immun. (2006) [Pubmed]
  2. Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog. Guida, M., Riedy, M., Lee, D., Hall, J. Pharmacogenetics (2000) [Pubmed]
  3. Identification of tryptase- and chymase-related gene clusters in human mast cells using microarrays. Dahl, C., Saito, H., Kruhøffer, M., Schiøtz, P.O. Allergy (2006) [Pubmed]
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