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Gene Review

Tpsb2  -  tryptase beta 2

Rattus norvegicus

Synonyms: Mast cell protease 6, Mcp6, Mcpt6, Tryptase beta-2, Tryptase-2, ...
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Disease relevance of Mcpt6

  • Tryptase Clara was shown to cleave the hemagglutinin and activate infectivity of influenza A virus in a dose-dependent way [1].
  • Tryptase Clara, an activating protease for Sendai virus in rat lungs, is involved in pneumopathogenicity [2].
  • These results suggest that PAR(2) activation elicited on PTCs by mast cell tryptase contributes to acute testicular inflammation and that this pathogenetic mechanism may also play a role in autoimmune orchitis [3].
  • Trypsin and tryptase, which are agonists for protease-activated receptor-2 (PAR-2), are involved in the pathogenesis of pancreatitis [4].
  • Tryptase Clara activates the infectivity of Sendai and influenza viruses proteolytically [5].

High impact information on Mcpt6


Chemical compound and disease context of Mcpt6


Biological context of Mcpt6


Anatomical context of Mcpt6

  • Tryptase Clara is an arginine-specific serine protease localized exclusively in and secreted from Clara cells of the bronchial epithelium of rats (H. Kido, Y. Yokogoshi, K. Sakai, M. Tashiro, Y. Kishino, A. Fukutomi, and N. Katunuma, J. Biol. Chem. 267:13573-13579, 1992) [2].
  • Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes [16].
  • In the progressed stage, tryptase Clara was hard to detect, with heavy accumulation of F2 antigen in the epithelial cells [5].
  • In thin sections embedded in LR White, gold particles indicating immunoreactivity of tryptase Clara were detected specifically in secretory granules of Clara cells [10].
  • On the other hand, AC-17 did significantly blocked the hyperpermeability induced in cultured bovine endothelial cells by tryptase, thrombin and proteinase-activated receptor-2 agonist peptide (SLIGKV-NH(2)) [17].

Associations of Mcpt6 with chemical compounds


Regulatory relationships of Mcpt6

  • Protease-activated receptor 2 (PAR2) is activated by trypsin and mast cell tryptase to induce widespread inflammation by unknown mechanisms [11].

Other interactions of Mcpt6


Analytical, diagnostic and therapeutic context of Mcpt6


  1. Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein. Kido, H., Yokogoshi, Y., Sakai, K., Tashiro, M., Kishino, Y., Fukutomi, A., Katunuma, N. J. Biol. Chem. (1992) [Pubmed]
  2. Tryptase Clara, an activating protease for Sendai virus in rat lungs, is involved in pneumopathogenicity. Tashiro, M., Yokogoshi, Y., Tobita, K., Seto, J.T., Rott, R., Kido, H. J. Virol. (1992) [Pubmed]
  3. Development of testicular inflammation in the rat involves activation of proteinase-activated receptor-2. Iosub, R., Klug, J., Fijak, M., Schneider, E., Fröhlich, S., Blumbach, K., Wennemuth, G., Sommerhoff, C.P., Steinhoff, M., Meinhardt, A. J. Pathol. (2006) [Pubmed]
  4. Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells. Masamune, A., Kikuta, K., Satoh, M., Suzuki, N., Shimosegawa, T. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  5. Sendai virus infection changes the subcellular localization of tryptase Clara in rat bronchiolar epithelial cells. Sakai, K., Kohri, T., Tashiro, M., Kishino, Y., Kido, H. Eur. Respir. J. (1994) [Pubmed]
  6. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. Kawabata, A., Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y., Kakehi, K. J. Clin. Invest. (2001) [Pubmed]
  7. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. Corvera, C.U., Déry, O., McConalogue, K., Böhm, S.K., Khitin, L.M., Caughey, G.H., Payan, D.G., Bunnett, N.W. J. Clin. Invest. (1997) [Pubmed]
  8. Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. Karlson, U., Pejler, G., Froman, G., Hellman, L. J. Biol. Chem. (2002) [Pubmed]
  9. Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia. Sayers, T.J., Wiltrout, T.A., Smyth, M.J., Ottaway, K.S., Pilaro, A.M., Sowder, R., Henderson, L.E., Sprenger, H., Lloyd, A.R. J. Immunol. (1994) [Pubmed]
  10. Electron immunohistochemical localization in rat bronchiolar epithelial cells of tryptase Clara, which determines the pneumotropism and pathogenicity of Sendai virus and influenza virus. Sakai, K., Kawaguchi, Y., Kishino, Y., Kido, H. J. Histochem. Cytochem. (1993) [Pubmed]
  11. Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa. Dinh, Q.T., Cryer, A., Dinh, S., Trevisani, M., Georgiewa, P., Chung, F., Geppetti, P., Heppt, W., Klapp, B.F., Fischer, A. Neuropeptides (2005) [Pubmed]
  12. Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats. Nishikawa, H., Kawai, K., Nishimura, S., Tanaka, S., Araki, H., Al-Ani, B., Hollenberg, M.D., Kuroda, R., Kawabata, A. Eur. J. Pharmacol. (2002) [Pubmed]
  13. Biological functions of serine proteases in the granules of rat mast cells. Katunuma, N., Fukusen, N., Kido, H. Adv. Enzyme Regul. (1986) [Pubmed]
  14. Rat mast cell tryptase. Lagunoff, D., Rickard, A., Marquardt, C. Arch. Biochem. Biophys. (1991) [Pubmed]
  15. Enzyme histochemistry of rat mast cell tryptase. Valchanov, K.P., Proctor, G.B., Hartley, R.H., Paterson, K.L., Shori, D.K. Histochem. J. (1998) [Pubmed]
  16. Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. Tsuji, A., Akamatsu, T., Nagamune, H., Matsuda, Y. Biochem. J. (1994) [Pubmed]
  17. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Sendo, T., Goromaru, T., Aki, K., Sakai, N., Itoh, Y., Oishi, R. Eur. J. Pharmacol. (2002) [Pubmed]
  18. Involvement of alpha-4 integrins in allergic airway responses and mast cell degranulation in vivo. Hojo, M., Maghni, K., Issekutz, T.B., Martin, J.G. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  19. Mast cell infiltration and chemokine expression in progressive renal disease. Jones, S.E., Kelly, D.J., Cox, A.J., Zhang, Y., Gow, R.M., Gilbert, R.E. Kidney Int. (2003) [Pubmed]
  20. Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions. Kido, H., Fukusen, N., Katunuma, N. Arch. Biochem. Biophys. (1985) [Pubmed]
  21. Traumatic brain injury results in mast cell increase and changes in regulation of central histamine receptors. Lozada, A., Maegele, M., Stark, H., Neugebauer, E.M., Panula, P. Neuropathol. Appl. Neurobiol. (2005) [Pubmed]
  22. Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Sabri, A., Muske, G., Zhang, H., Pak, E., Darrow, A., Andrade-Gordon, P., Steinberg, S.F. Circ. Res. (2000) [Pubmed]
  23. Tryptase from rat skin: purification and properties. Braganza, V.J., Simmons, W.H. Biochemistry (1991) [Pubmed]
  24. Expression of mast cell proteases in rat lung during helminth infection: mast cells express both rat mast cell protease II and tryptase in helminth infected lung. Tomita, M., Itoh, H., Kobayashi, T., Onitsuka, T., Nawa, Y. Int. Arch. Allergy Immunol. (1999) [Pubmed]
  25. Mast cell, myofibroblast and nerve terminal complexes in carbon tetrachloride-induced cirrhotic rat livers. Akiyoshi, H., Terada, T. J. Hepatol. (1998) [Pubmed]
  26. Induction of mast cell activation and CC chemokine responses in remodeling tracheal allografts. Cruz, A.C., Hall, T.S., Jones, K.D., Edwards, S.T., Fang, K.C. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  27. Pulmonary surfactant is a potential endogenous inhibitor of proteolytic activation of Sendai virus and influenza A virus. Kido, H., Sakai, K., Kishino, Y., Tashiro, M. FEBS Lett. (1993) [Pubmed]
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