Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

cmlc1 - cardiac myosin light chain-1

Danio rerio

Synonyms: SO:0000704

Huang, C.J. et al., Ho, Y.L. et al., Huang, C.J. et al.

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High impact information on cmlc1

To develop the first heart-specific tetracycline (Tet)-On system in zebrafish, we constructed plasmids in which the cardiac myosin light chain 2 promoter of zebrafish was used to drive the reverse Tet-controlled transactivator (rtTA) and the green fluorescent protein (GFP) reporter gene was preceded by an rtTA-responsive element [1].
Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish [2].
Methods: We cloned a 1.6 kb polymerase chain reaction (PCR) product containing the upstream sequence (870 bp), exon 1 (39 bp), intron 1 (682 bp), and exon 2 (69 bp) of the zebrafish cardiac myosin light chain 2 gene [3].

References

Conditional expression of a myocardium-specific transgene in zebrafish transgenic lines. Huang, C.J., Jou, T.S., Ho, Y.L., Lee, W.H., Jeng, Y.T., Hsieh, F.J., Tsai, H.J. Dev. Dyn. (2005) [Pubmed]
Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish. Huang, C.J., Tu, C.T., Hsiao, C.D., Hsieh, F.J., Tsai, H.J. Dev. Dyn. (2003) [Pubmed]
In Vivo Assessment of Cardiac Morphology and Function in Heart-specific Green Fluorescent Zebrafish. Ho, Y.L., Lin, Y.H., Tsai, I.J., Hsieh, F.J., Tsai, H.J. J. Formos. Med. Assoc. (2007) [Pubmed]

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