Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SMARCC2 - SWI/SNF related, matrix associated, actin...

Homo sapiens

Synonyms: BAF170, BRG1-associated factor 170, CRACC2, Rsc8, SWI/SNF complex 170 kDa subunit, ...

O'Neill, D. et al., Chen, J. et al., Battaglioli, E. et al., Foster, K.S. et al., Wang, W. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SMARCC2

We have isolated cDNAs for human BAF155, BAF170, and BAF60 [1].
Mass spectrometric identification of purified peptides and antibody supershift assays indicate that PYR complex contains at least four known mammalian SWI/SNF subunits: BAF57, INI1, BAF60a, and BAF170 [2].
Microinjection of specific antibodies against BRG1, BAF57, or BAF170 into Rat1 fibroblasts relieves repression of RE1 reporter genes [3].

Anatomical context of SMARCC2

Activation of Akt in HeLa cells resulted in its association with hSWI/SNF subunits: INI1, BAF155 and BAF170, as well as actin [4].

Other interactions of SMARCC2

Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57 [5].

References

Diversity and specialization of mammalian SWI/SNF complexes. Wang, W., Xue, Y., Zhou, S., Kuo, A., Cairns, B.R., Crabtree, G.R. Genes Dev. (1996) [Pubmed]
Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. O'Neill, D., Yang, J., Erdjument-Bromage, H., Bornschlegel, K., Tempst, P., Bank, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
REST repression of neuronal genes requires components of the hSWI.SNF complex. Battaglioli, E., Andrés, M.E., Rose, D.W., Chenoweth, J.G., Rosenfeld, M.G., Anderson, M.E., Mandel, G. J. Biol. Chem. (2002) [Pubmed]
Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt. Foster, K.S., McCrary, W.J., Ross, J.S., Wright, C.F. Oncogene (2006) [Pubmed]
Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. Chen, J., Archer, T.K. Mol. Cell. Biol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP003118	Anopheles gambiae str. PEST
SMARCC2	Bos taurus
SMARCC2	Canis lupus familiaris
smarcc2	Danio rerio
mor	Drosophila melanogaster
SMARCC2	Macaca mulatta
Smarcc2	Mus musculus
SMARCC2	Pan troglodytes
LOC685179	Rattus norvegicus
smarcc2	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.