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Gene Review

SMARCC1  -  SWI/SNF related, matrix associated, actin...

Homo sapiens

Synonyms: BAF155, BRG1-associated factor 155, CRACC1, Rsc8, SRG3, ...
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Disease relevance of SMARCC1

  • Interestingly, the gene encoding the BAF155/hSWI3 subunit of the complex maps to 3p21-p23, an area of chromosomal deletion seen in a number of human adenocarcinomas including breast, kidney, pancreas, and ovary [1].

High impact information on SMARCC1

  • In addition, we have found that Brg1, hBrm, and BAF155 can interact specifically with mSin3A in vitro, showing a direct association of hSWI/SNF complexes with proteins involved in gene repression [2].
  • Remodeling is achieved with only the BRG1-BAF155 minimal complex and the EKLF zinc finger DBD, whereas transcription requires, in addition, an activation domain [3].
  • We have isolated cDNAs for human BAF155, BAF170, and BAF60 [4].
  • SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development [5].
  • The Swi3 SWIRM forms a four-helix bundle containing a pseudo 2-fold axis and a helix-turn-helix motif commonly found in DNA-binding proteins [6].

Biological context of SMARCC1

  • BAF155 became preferentially recognized by an antibody that detects phosphorylated Akt substrates upon activation of Akt, suggesting that BAF155 may be an in vivo target for phosphorylation by Akt [7].
  • We have previously reported that SRG3 is critical in determining the sensitivity for the GC-induced apoptosis in developing thymocytes [8].
  • We report here that Notch signaling downregulates the transcriptional activation of SRG3 through N-box and/or E-box elements on its promoter [8].
  • These results suggest that the multiple positive regulatory mechanisms of AR transactivation by SRG3 may be important for the rapid proliferation of prostate cells during prostate development and regeneration [9].
  • When expressed in Saccharomyces cerevisiae, the cDNA encoding AtSWI3B partially complements the swi3 mutant phenotype [10].

Anatomical context of SMARCC1

  • Activation of Akt in HeLa cells resulted in its association with hSWI/SNF subunits: INI1, BAF155 and BAF170, as well as actin [7].
  • In this study, we demonstrate that, upon activation, CRACC associates with a homolog of SAP, Ewing's sarcoma's/FLI1-activated transcript 2 (EAT-2), in human NK cells [11].

Associations of SMARCC1 with chemical compounds


Regulatory relationships of SMARCC1


Other interactions of SMARCC1


  1. Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. Decristofaro, M.F., Betz, B.L., Rorie, C.J., Reisman, D.N., Wang, W., Weissman, B.E. J. Cell. Physiol. (2001) [Pubmed]
  2. Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Sif, S., Saurin, A.J., Imbalzano, A.N., Kingston, R.E. Genes Dev. (2001) [Pubmed]
  3. Functional selectivity of recombinant mammalian SWI/SNF subunits. Kadam, S., McAlpine, G.S., Phelan, M.L., Kingston, R.E., Jones, K.A., Emerson, B.M. Genes Dev. (2000) [Pubmed]
  4. Diversity and specialization of mammalian SWI/SNF complexes. Wang, W., Xue, Y., Zhou, S., Kuo, A., Cairns, B.R., Crabtree, G.R. Genes Dev. (1996) [Pubmed]
  5. SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development. Sarnowski, T.J., Ríos, G., Jásik, J., Swiezewski, S., Kaczanowski, S., Li, Y., Kwiatkowska, A., Pawlikowska, K., Koźbiał, M., Koźbiał, P., Koncz, C., Jerzmanowski, A. Plant Cell (2005) [Pubmed]
  6. Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Da, G., Lenkart, J., Zhao, K., Shiekhattar, R., Cairns, B.R., Marmorstein, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt. Foster, K.S., McCrary, W.J., Ross, J.S., Wright, C.F. Oncogene (2006) [Pubmed]
  8. Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter. Jang, J., Choi, Y.I., Choi, J., Lee, K.Y., Chung, H., Jeon, S.H., Seong, R.H. Cell Death Differ. (2006) [Pubmed]
  9. Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways. Hong, C.Y., Suh, J.H., Kim, K., Gong, E.Y., Jeon, S.H., Ko, M., Seong, R.H., Kwon, H.B., Lee, K. Mol. Cell. Biol. (2005) [Pubmed]
  10. AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf chromatin remodeling complex, interacts with FCA, a regulator of flowering time. Sarnowski, T.J., Swiezewski, S., Pawlikowska, K., Kaczanowski, S., Jerzmanowski, A. Nucleic Acids Res. (2002) [Pubmed]
  11. The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. Tassi, I., Colonna, M. J. Immunol. (2005) [Pubmed]
  12. Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. Chen, J., Archer, T.K. Mol. Cell. Biol. (2005) [Pubmed]
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