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Gene Review

SMARCE1  -  SWI/SNF related, matrix associated, actin...

Homo sapiens

Synonyms: BAF57, BRG1-associated factor 57, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Disease relevance of SMARCE1


High impact information on SMARCE1

  • Moreover, chromatin immunoprecipitation assays demonstrated that BAF57 is recruited to the estrogen-responsive promoter, pS2, in a ligand-dependent manner [2].
  • Mass spectrometric identification of purified peptides and antibody supershift assays indicate that PYR complex contains at least four known mammalian SWI/SNF subunits: BAF57, INI1, BAF60a, and BAF170 [3].
  • Furthermore, the protein levels of BAF155/170 dictate the maximum cellular amount of BAF57 [4].
  • This down-regulation process is mediated by an increase in proteasome-dependent degradation of the BAF57 protein [4].
  • BT549 is an invasive human breast carcinoma cell line that lacks expression of BAF57, a key hSWI/SNF subunit that mediates interaction with transcriptional activators and corepressors [5].

Chemical compound and disease context of SMARCE1

  • Different experimental manipulations leading to the abrogation of BAF57 expression and/or function severely reduced the expression of various endogenous ER target genes and blocked estrogen-stimulated proliferation in ZR-75-1 breast cancer cells [6].

Biological context of SMARCE1


Associations of SMARCE1 with chemical compounds

  • These results suggest that one of the mechanisms for recruiting SWI/SNF complexes to estrogen target genes is by means of BAF57 [2].

Physical interactions of SMARCE1


Other interactions of SMARCE1


  1. Identification of BAF57 mutations in human breast cancer cell lines. Kiskinis, E., García-Pedrero, J.M., Villaronga, M.A., Parker, M.G., Belandia, B. Breast Cancer Res. Treat. (2006) [Pubmed]
  2. Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. Belandia, B., Orford, R.L., Hurst, H.C., Parker, M.G. EMBO J. (2002) [Pubmed]
  3. Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. O'Neill, D., Yang, J., Erdjument-Bromage, H., Bornschlegel, K., Tempst, P., Bank, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. Chen, J., Archer, T.K. Mol. Cell. Biol. (2005) [Pubmed]
  5. The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene. Wang, L., Baiocchi, R.A., Pal, S., Mosialos, G., Caligiuri, M., Sif, S. Mol. Cell. Biol. (2005) [Pubmed]
  6. The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells. García-Pedrero, J.M., Kiskinis, E., Parker, M.G., Belandia, B. J. Biol. Chem. (2006) [Pubmed]
  7. REST repression of neuronal genes requires components of the hSWI.SNF complex. Battaglioli, E., Andrés, M.E., Rose, D.W., Chenoweth, J.G., Rosenfeld, M.G., Anderson, M.E., Mandel, G. J. Biol. Chem. (2002) [Pubmed]
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