The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SOX1  -  SRY (sex determining region Y)-box 1

Homo sapiens

Synonyms: Transcription factor SOX-1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on SOX1

  • The HMG-box transcription factors Sox1, Sox2 and Sox3 (Sox1-3) have previously been shown to suppress neurogenesis by maintaining neural cells in an undifferentiated state [1].
  • The DC5 site was equally bound and bent by the HMG domains of SOX1/2 and SOX9 [2].
  • The Dichaete gene of Drosophila encodes a group B Sox protein related to mammalian Sox1, -2, and -3 and, like these proteins, it is widely and dynamically expressed throughout embryogenesis [3].
  • There is no evidence for clustering of other members of the SOX1, -2, and -3 or SOX4 gene families around the SOX4 locus [4].
  • SOX2 gene at human chromosome 3q26.33, SOX1 gene at 13q34, and SOX3 gene at Xq27.1 constitute a subfamily among the SOX gene family [5].
 

Biological context of SOX1

  • RESULTS: Antibodies to SOX1 were present in 28% of patients and another 28% had anti-ZIC2 antibodies, classifying these as some of the most frequent antibody responses observed in SCLC [6].
 

Anatomical context of SOX1

  • However, the cell markers associated with cells expressing proliferative cell nuclear antigen (PCNA) and Sox1 differed between late embryonic and adult hippocampus, suggesting that there are important differences between adult and embryonic neurogenesis [7].
  • In this study, we examined dividing cells in the late embryonic and adult rat hippocampus to identify distinguishing characteristics and potential neural stem cell population(s), as identified by the putative neural stem cell markers FGFR4 and Sox1 [7].
 

Associations of SOX1 with chemical compounds

  • Seroreactivity against either SOX1 or ZIC2 correlated with younger age, lower lactate dehydrogenase levels, and better response to initial therapy [6].
 

Other interactions of SOX1

  • Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters [6].
  • Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9 [2].

References

  1. Sox21 promotes the progression of vertebrate neurogenesis. Sandberg, M., Källström, M., Muhr, J. Nat. Neurosci. (2005) [Pubmed]
  2. Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Kamachi, Y., Cheah, K.S., Kondoh, H. Mol. Cell. Biol. (1999) [Pubmed]
  3. Regulatory mutations of the Drosophila Sox gene Dichaete reveal new functions in embryonic brain and hindgut development. Sánchez-Soriano, N., Russell, S. Dev. Biol. (2000) [Pubmed]
  4. Characterization and mapping of the human SOX4 gene. Farr, C.J., Easty, D.J., Ragoussis, J., Collignon, J., Lovell-Badge, R., Goodfellow, P.N. Mamm. Genome (1993) [Pubmed]
  5. Comparative genomics on SOX2 orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  6. Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters. Vural, B., Chen, L.C., Saip, P., Chen, Y.T., Ustuner, Z., Gonen, M., Simpson, A.J., Old, L.J., Ozbek, U., Gure, A.O. Cancer (2005) [Pubmed]
  7. Distinguishing features of progenitor cells in the late embryonic and adult hippocampus. Limke, T.L., Cai, J., Miura, T., Rao, M.S., Mattson, M.P. Dev. Neurosci. (2003) [Pubmed]
 
WikiGenes - Universities