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Gene Review

Nrarp  -  Notch-regulated ankyrin repeat protein

Mus musculus

Synonyms: 2700054M22Rik, Notch-regulated ankyrin repeat-containing protein
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High impact information on Nrarp


Biological context of Nrarp

  • A 4.4 kb genomic fragment of the mouse Nrarp locus containing those conserved regions and fused to a luciferase reporter gene showed basal promoter activity in 293T cells and this activity was strongly increased by the intracellular domain of Notch, NICD [3].
  • We show here that both mouse and human promoter regions of Nrarp share two conserved regions located approximately 2 and approximately 3 kb upstream of the transcription start site each containing a perfect putative binding site for the Notch-dependent transcription factor Su(H) [3].

Anatomical context of Nrarp


Analytical, diagnostic and therapeutic context of Nrarp


  1. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. Yun, T.J., Bevan, M.J. J. Immunol. (2003) [Pubmed]
  2. The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Krebs, L.T., Deftos, M.L., Bevan, M.J., Gridley, T. Dev. Biol. (2001) [Pubmed]
  3. Direct regulation of the Nrarp gene promoter by the Notch signaling pathway. Pirot, P., van Grunsven, L.A., Marine, J.C., Huylebroeck, D., Bellefroid, E.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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