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Gene Review

Hrnr  -  hornerin

Mus musculus

Synonyms: 1110033K19Rik, A530063N20Rik, AV011854, Hornerin, S100a18
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High impact information on Hrnr

  • Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin [1].
  • Hornerin was expressed in the tongue, esophagus, forestomach, and skin among the adult mouse tissues examined, all of them cornifying stratified epithelium [1].
  • Differentiation of primary mouse epidermal keratinocytes with 0.12 mm Ca(2+) resulted in the induction of hornerin [1].
  • The repetitive domain of hornerin was found to be rich in glycine, serine, and glutamine [1].
  • Hornerin, which has 2,496 amino acids, comprises EF-hand domains at the N terminus followed by a spacer sequence and a large repetitive domain, indicating that hornerin is a novel member of the "fused gene"-type cornified envelope precursor protein family [1].

Anatomical context of Hrnr


Other interactions of Hrnr

  • In this study we examined the expression of hornerin compared with that of profilaggrin in various mouse tissues [2].

Analytical, diagnostic and therapeutic context of Hrnr

  • Furthermore, Western blot analysis of the mouse skin showed that the hornerin protein was cleaved during the process of epidermal differentiation, indicating possible posttranslational proteolytic processing as is observed in profilaggrin [1].


  1. Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin. Makino, T., Takaishi, M., Morohashi, M., Huh, N.H. J. Biol. Chem. (2001) [Pubmed]
  2. Expression of hornerin in stratified squamous epithelium in the mouse: a comparative analysis with profilaggrin. Makino, T., Takaishi, M., Toyoda, M., Morohashi, M., Huh, N.H. J. Histochem. Cytochem. (2003) [Pubmed]
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