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Gene Review

TARBP1  -  TAR (HIV-1) RNA binding protein 1

Homo sapiens

Synonyms: TAR RNA-binding protein 1, TAR RNA-binding protein of 185 kDa, TRM3, TRP-185, TRP185
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Disease relevance of TARBP1


High impact information on TARBP1


Enzymatic interactions of TARBP1

  • In this study we demonstrated that a set of cellular cofactors that modulate the binding of the cellular protein TRP-185 to the TAR RNA loop sequences also functioned to markedly stimulate the specific binding of hypophosphorylated (IIa) and hyperphosphorylated (IIo) RNA polymerase II to TAR RNA [4].

Other interactions of TARBP1


  1. tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. Wu, F., Garcia, J., Sigman, D., Gaynor, R. Genes Dev. (1991) [Pubmed]
  2. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. Wu-Baer, F., Lane, W.S., Gaynor, R.B. EMBO J. (1995) [Pubmed]
  3. Adeno-Associated Virus Site-Specific Integration Is Regulated by TRP-185. Yamamoto, N., Suzuki, M., Kawano, M.A., Inoue, T., Takahashi, R.U., Tsukamoto, H., Enomoto, T., Yamaguchi, Y., Wada, T., Handa, H. J. Virol. (2007) [Pubmed]
  4. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Wu-Baer, F., Sigman, D., Gaynor, R.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
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