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Gene Review:

TARBP1 - TAR (HIV-1) RNA binding protein 1

Homo sapiens

Synonyms: TAR RNA-binding protein 1, TAR RNA-binding protein of 185 kDa, TRM3, TRP-185, TRP185

Wu-Baer, F. et al., Yamamoto, N. et al., Wu-Baer, F. et al., Wu, F. et al.

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Disease relevance of TARBP1

These results characterize a positively acting cellular RNA-binding factor, TRP-185, which is involved in the regulation of HIV gene expression [1].
The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA [2].
Adeno-Associated Virus Site-Specific Integration Is Regulated by TRP-185 [3].

High impact information on TARBP1

This analysis indicated that only two cellular factors, RNA polymerase II and the previously characterized TAR RNA loop binding protein TRP-185, were capable of binding specifically to TAR RNA [2].
TAR RNA loop binding protein 185 (TRP-185), previously reported to associate with human immunodeficiency virus type 1 TAR RNA, binds to AAVS1 DNA [3].

Enzymatic interactions of TARBP1

In this study we demonstrated that a set of cellular cofactors that modulate the binding of the cellular protein TRP-185 to the TAR RNA loop sequences also functioned to markedly stimulate the specific binding of hypophosphorylated (IIa) and hyperphosphorylated (IIo) RNA polymerase II to TAR RNA [4].

Other interactions of TARBP1

In gel-retardation assays, the binding of both recombinant TRP-185 and RNA polymerase II was dependent on the presence of an additional group of proteins designated cellular cofactors [2].

References

tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. Wu, F., Garcia, J., Sigman, D., Gaynor, R. Genes Dev. (1991) [Pubmed]
The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. Wu-Baer, F., Lane, W.S., Gaynor, R.B. EMBO J. (1995) [Pubmed]
Adeno-Associated Virus Site-Specific Integration Is Regulated by TRP-185. Yamamoto, N., Suzuki, M., Kawano, M.A., Inoue, T., Takahashi, R.U., Tsukamoto, H., Enomoto, T., Yamaguchi, Y., Wada, T., Handa, H. J. Virol. (2007) [Pubmed]
Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Wu-Baer, F., Sigman, D., Gaynor, R.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]

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