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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MLX  -  MLX, MAX dimerization protein

Homo sapiens

Synonyms: BHLHD13, Class D basic helix-loop-helix protein 13, MAD7, MXD7, Max-like bHLHZip protein, ...
 
 
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Disease relevance of MLX

  • The stomachs of the IND (1 and 2 mg/kg) groups presented hemorrhage and ulcers, whereas in the MLX-treated groups, there were mild petechiae just in the 3 mg/kg group [1].
  • MLX may provide a better risk/benefit ratio in the treatment of human periodontitis than non-selective COX inhibitors [1].
 

High impact information on MLX

  • WBSCR14 forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence CACGTG [2].
  • The isolates included an oncogenic variant (MAD-4), an antigenic variant (MAD-11), and two different isolates derived from the urine (MAD-7) and from the brain (MAD-8) of the same patient [3].
  • Type I DNA was defined as that typified by the prototype virus, MAD-1; Type II, that typified by viral DNA molecularly cloned from brain tissue of the MAD-7/8 patient (BrC-8 DNA) [4].
  • The DNAs of these isolates, MAD-7 and MAD-8 respectively, were shown in this study to be mixtures of several different full-length genomes [4].
  • Luminescence was measured with a Dynex MLX luminometer after addition of the aldehyde substrate [5].
 

Analytical, diagnostic and therapeutic context of MLX

References

  1. Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. Bezerra, M.M., de Lima, V., Alencar, V.B., Vieira, I.B., Brito, G.A., Ribeiro, R.A., Rocha, F.A. J. Periodontol. (2000) [Pubmed]
  2. WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. Cairo, S., Merla, G., Urbinati, F., Ballabio, A., Reymond, A. Hum. Mol. Genet. (2001) [Pubmed]
  3. Differences in regulatory sequences of naturally occurring JC virus variants. Martin, J.D., King, D.M., Slauch, J.M., Frisque, R.J. J. Virol. (1985) [Pubmed]
  4. Multiple JC virus genomes from one patient. Martin, J.D., Foster, G.C. J. Gen. Virol. (1984) [Pubmed]
  5. Quantitative detection of crystalline lysine supplementation in poultry feeds using a rapid bacterial bioluminescence assay. Zabala Díaz, I.B., Ricke, S.C. Appl. Microbiol. Biotechnol. (2003) [Pubmed]
  6. European Clinical Trials Directive: responses made to MHRA consultation letter MLX 287. Flavell, D.J., Flavell, S.U., Sullivan, R. Lancet (2003) [Pubmed]
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