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Gene Review:

Dab2ip - disabled 2 interacting protein

Mus musculus

Synonyms: 2310011D08Rik, AI480459, AIP1, ASK-interacting protein 1, Aip1, ...

Chen, H. et al., Zhang, H. et al.

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Disease relevance of Dab2ip

It appears that epigenetic regulation, particularly histone acetylation of the Dab2ip gene promoter, plays an important role in modulating its gene expression in the mouse prostate cancer cell [1].

High impact information on Dab2ip

Here, we isolated a mouse Dab2ip gene with a highly homologous sequence to that of the human and rat gene and mapped it at chromosome 2B [1].
Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate [1].

Other interactions of Dab2ip

In vitro, VEGF-induced EC migration was inhibited by AIP1 overexpression, whereas it was augmented by both AIP1 knockout and knockdown, with the enhanced EC migration caused by AIP1 knockdown being associated with increased VEGFR2 signaling [2].

References

Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate. Chen, H., Karam, J.A., Schultz, R., Zhang, Z., Duncan, C., Hsieh, J.T. DNA Cell Biol. (2006) [Pubmed]
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. Zhang, H., He, Y., Dai, S., Xu, Z., Luo, Y., Wan, T., Luo, D., Jones, D., Tang, S., Chen, H., Sessa, W.C., Min, W. J. Clin. Invest. (2008) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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dab2ipa	Danio rerio
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DAB2IP	Homo sapiens
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