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Gene Review

Dab2ip  -  disabled 2 interacting protein

Mus musculus

Synonyms: 2310011D08Rik, AI480459, AIP1, ASK-interacting protein 1, Aip1, ...
 
 
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Disease relevance of Dab2ip

 

High impact information on Dab2ip

 

Other interactions of Dab2ip

  • In vitro, VEGF-induced EC migration was inhibited by AIP1 overexpression, whereas it was augmented by both AIP1 knockout and knockdown, with the enhanced EC migration caused by AIP1 knockdown being associated with increased VEGFR2 signaling [2].

References

  1. Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate. Chen, H., Karam, J.A., Schultz, R., Zhang, Z., Duncan, C., Hsieh, J.T. DNA Cell Biol. (2006) [Pubmed]
  2. AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. Zhang, H., He, Y., Dai, S., Xu, Z., Luo, Y., Wan, T., Luo, D., Jones, D., Tang, S., Chen, H., Sessa, W.C., Min, W. J. Clin. Invest. (2008) [Pubmed]
 
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