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Gene Review

DAB2IP  -  DAB2 interacting protein

Homo sapiens

Synonyms: AF9Q34, AIP-1, AIP1, ASK-interacting protein 1, DAB2 interaction protein, ...
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Disease relevance of DAB2IP


High impact information on DAB2IP


Chemical compound and disease context of DAB2IP


Biological context of DAB2IP


Anatomical context of DAB2IP


Associations of DAB2IP with chemical compounds


Other interactions of DAB2IP

  • Previously we have shown that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway [9].
  • Human DAB2IP (for DAB2 interaction protein) is a novel member of the RasGTPase-activating protein family [7].
  • In conclusion, aberrant methylation and abnormal protein expression of the caveolin-1-gene is involved in the formation of nonurothelial carcinomas of the urinary bladder and promoter methylation of the hDAB2IP gene in the progression of TCC from a low to a high malignant potential [10].
  • From an AML-M5 with a t(9;11)(q34;q23), we identified a novel MLL fusion partner, AF9Q34 [11].

Analytical, diagnostic and therapeutic context of DAB2IP


  1. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. Chen, H., Tu, S.W., Hsieh, J.T. J. Biol. Chem. (2005) [Pubmed]
  2. Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Dote, H., Toyooka, S., Tsukuda, K., Yano, M., Ouchida, M., Doihara, H., Suzuki, M., Chen, H., Hsieh, J.T., Gazdar, A.F., Shimizu, N. Clin. Cancer Res. (2004) [Pubmed]
  3. Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers. Yano, M., Toyooka, S., Tsukuda, K., Dote, H., Ouchida, M., Hanabata, T., Aoe, M., Date, H., Gazdar, A.F., Shimizu, N. Int. J. Cancer (2005) [Pubmed]
  4. Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. Dote, H., Toyooka, S., Tsukuda, K., Yano, M., Ota, T., Murakami, M., Naito, M., Toyota, M., Gazdar, A.F., Shimizu, N. Br. J. Cancer (2005) [Pubmed]
  5. AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. Zhang, R., He, X., Liu, W., Lu, M., Hsieh, J.T., Min, W. J. Clin. Invest. (2003) [Pubmed]
  6. Mutational analysis of the p53 core domain L1 loop. Zupnick, A., Prives, C. J. Biol. Chem. (2006) [Pubmed]
  7. Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization. Chen, H., Pong, R.C., Wang, Z., Hsieh, J.T. Genomics (2002) [Pubmed]
  8. Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines. Chen, H., Toyooka, S., Gazdar, A.F., Hsieh, J.T. J. Biol. Chem. (2003) [Pubmed]
  9. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. Zhang, H., Zhang, R., Luo, Y., D'Alessio, A., Pober, J.S., Min, W. J. Biol. Chem. (2004) [Pubmed]
  10. Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements. Kunze, E., Von Bonin, F., Werner, C., Wendt, M., Schlott, T. Int. J. Mol. Med. (2006) [Pubmed]
  11. Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia. von Bergh, A.R., Wijers, P.M., Groot, A.J., van Zelderen-Bhola, S., Falkenburg, J.H., Kluin, P.M., Schuuring, E. Genes Chromosomes Cancer (2004) [Pubmed]
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