The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

P2ry12  -  purinergic receptor P2Y, G-protein coupled 12

Mus musculus

Synonyms: 2900079B22Rik, 4921504D23Rik, P2Y purinoceptor 12, P2Y12
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on P2ry12

  • ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12 [1].
  • P2Y12 has been shown to be the target of the thienopyridine drugs, ticlopidine and clopidogrel [1].
  • The second wave of platelet secretion and aggregation required the first wave of both ADP secretion and aggregation and were blocked by either the integrin inhibitor RGDS or a P2Y12 receptor antagonist, indicating a requirement for both the integrin outside-in signal and ADP-activated Gi pathway [2].
  • In Galpha(q)-deficient platelets that do not respond with activation of integrin alpha(IIb)beta(3) to a variety of mediators like thromboxane A2 (TXA2), thrombin, or ADP, collagen at high concentrations was able to induce aggregation, an effect that could be blocked by antagonists of the TXA2 or P2Y12 receptors [3].
  • We demonstrate that aggregation induced by threshold concentrations of convulxin undergoes synergy with ADP acting via the P2Y12 receptor whereas there is no synergy via the P2Y1 receptor or with thromboxanes [4].

Associations of P2ry12 with chemical compounds

  • The P2Y12 receptor appeared unable to activate the GTPase per se as also observed for the adenosine triphosphate receptor P2X1 [5].
  • On the other hand, apyrase, the P2Y12 receptor antagonist, AR-C67085, and indomethacin only marginally inhibit aggregation induced by convulxin [4].
  • The activation of TXA2 or P2Y12 receptors alone, which in Galpha(q)-deficient platelets couple to G12/G13 and Gi, respectively, did not induce platelet integrin activation or aggregation [3].

Regulatory relationships of P2ry12

  • Conversely, secreted ADP strongly potentiated Rac activation induced by FcgammaRIIa clustering or TRAP via its P2Y12 receptor, the target of antithrombotic thienopyridines [5].

Other interactions of P2ry12

  • Combination of P2Y1 deficiency with P2Y12 inhibition led to a significant additive effect [6].
  • However, this aggregation is independent of Galphaq and TxA2 signaling in response to high LSA concentrations, but is dependent on ADP signaling through its receptor P2Y12, and therefore presumably Gi, regardless of the level of LSA used to activate the platelets [7].


  1. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. Foster, C.J., Prosser, D.M., Agans, J.M., Zhai, Y., Smith, M.D., Lachowicz, J.E., Zhang, F.L., Gustafson, E., Monsma, F.J., Wiekowski, M.T., Abbondanzo, S.J., Cook, D.N., Bayne, M.L., Lira, S.A., Chintala, M.S. J. Clin. Invest. (2001) [Pubmed]
  2. Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. Li, Z., Zhang, G., Le Breton, G.C., Gao, X., Malik, A.B., Du, X. J. Biol. Chem. (2003) [Pubmed]
  3. Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. Nieswandt, B., Schulte, V., Zywietz, A., Gratacap, M.P., Offermanns, S. J. Biol. Chem. (2002) [Pubmed]
  4. Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin. Atkinson, B.T., Stafford, M.J., Pears, C.J., Watson, S.P. Eur. J. Biochem. (2001) [Pubmed]
  5. A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation. Soulet, C., Hechler, B., Gratacap, M.P., Plantavid, M., Offermanns, S., Gachet, C., Payrastre, B. J. Thromb. Haemost. (2005) [Pubmed]
  6. Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist. Lenain, N., Freund, M., Léon, C., Cazenave, J.P., Gachet, C. J. Thromb. Haemost. (2003) [Pubmed]
  7. AlphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. Cho, M.J., Liu, J., Pestina, T.I., Steward, S.A., Jackson, C.W., Gartner, T.K. J. Thromb. Haemost. (2003) [Pubmed]
WikiGenes - Universities