The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

P2ry12  -  purinergic receptor P2Y, G-protein coupled...

Rattus norvegicus

Synonyms: P2Y purinoceptor 12, P2Y12, P2Y12 platelet ADP receptor, P2y12
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of P2ry12

  • Our data suggest that secretion of endogenous ADP and subsequent P2Y12-mediated signaling are critical for platelet aggregation, platelet spreading, and as a consequence, for stabilization of thrombus [1].
  • Previously it was shown that stimulation of the P2Y12 receptor activates PKB signalling in C6 glioma cells [K. Van Kolen and H. Slegers, J. Neurochem. 89, 442.]. In the present study, the mechanisms involved in this response were further elucidated [2].
 

High impact information on P2ry12

  • The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts [3].
  • In addition, we showed the predominant association of P2Y12 oligomers to cell membrane lipid rafts and the partitioning of P2Y12 out of rafts in response to clopidogrel and Act-Met [3].
  • Finally, using a series of receptors individually mutated at each cysteine residue and a chimeric P2Y12/P2Y13 receptor, we pointed out the involvement of cysteine 97 within the first extracellular loop of P2Y12 in the mechanism of action of Act-Met [3].
  • P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been recently identified as the receptor targeted by the antithrombotic drug, clopidogrel [3].
  • The raft-associated P2Y12 oligomers represented the functional form of the receptor, as demonstrated by binding and signal transduction studies [3].
 

Biological context of P2ry12

 

Anatomical context of P2ry12

 

Associations of P2ry12 with chemical compounds

  • P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B [8].
  • To investigate how P2Y receptors are activated in a neuronal environment, we used PC12 cells in which nucleotides were found to elicit increases in inositol phosphates via P2Y2 and decreases in cAMP via P2Y12 receptors [9].
  • These results indicate that nucleoside diphosphate-sensitive (P2Y12 and P2Y1) receptors are activated by spontaneous nucleotide release, whereas triphosphate-sensitive (P2Y2) receptors require an excess of depolarization-evoked release to become activated [9].
 

Other interactions of P2ry12

  • 5. In conclusion, the data suggest that P2Y (P2Y1 or P2Y12) receptor subtypes are involved in the generation of astrogliosis in the NAc of rats, with a possible minor contribution of P2X receptor subtypes [10].
 

Analytical, diagnostic and therapeutic context of P2ry12

References

  1. Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon. Shiraga, M., Miyata, S., Kato, H., Kashiwagi, H., Honda, S., Kurata, Y., Tomiyama, Y., Kanakura, Y. J. Thromb. Haemost. (2005) [Pubmed]
  2. P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Van Kolen, K., Gilany, K., Moens, L., Esmans, E.L., Slegers, H. Cell. Signal. (2006) [Pubmed]
  3. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Savi, P., Zachayus, J.L., Delesque-Touchard, N., Labouret, C., Hervé, C., Uzabiaga, M.F., Pereillo, J.M., Culouscou, J.M., Bono, F., Ferrara, P., Herbert, J.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin: different regulations by ADP through PKA. Nasu-Tada, K., Koizumi, S., Inoue, K. Glia (2005) [Pubmed]
  5. Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells. Czajkowski, R., Banachewicz, W., Ilnytska, O., Drobot, L.B., Baranska, J. Br. J. Pharmacol. (2004) [Pubmed]
  6. Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Sasaki, Y., Hoshi, M., Akazawa, C., Nakamura, Y., Tsuzuki, H., Inoue, K., Kohsaka, S. Glia (2003) [Pubmed]
  7. Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. Lechner, S.G., Dorostkar, M.M., Mayer, M., Edelbauer, H., Pankevych, H., Boehm, S. Eur. J. Neurosci. (2004) [Pubmed]
  8. P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. Van Kolen, K., Slegers, H. J. Neurochem. (2004) [Pubmed]
  9. Activity-dependent autocrine-paracrine activation of neuronal P2Y receptors. Moskvina, E., Unterberger, U., Boehm, S. J. Neurosci. (2003) [Pubmed]
  10. P2 receptor-types involved in astrogliosis in vivo. Franke, H., Krügel, U., Schmidt, R., Grosche, J., Reichenbach, A., Illes, P. Br. J. Pharmacol. (2001) [Pubmed]
  11. 2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12. Vasiljev, K.S., Uri, A., Laitinen, J.T. Neuropharmacology (2003) [Pubmed]
 
WikiGenes - Universities