Gene Review:
P2ry12 - purinergic receptor P2Y, G-protein coupled...
Rattus norvegicus
Synonyms:
P2Y purinoceptor 12, P2Y12, P2Y12 platelet ADP receptor, P2y12
- Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon. Shiraga, M., Miyata, S., Kato, H., Kashiwagi, H., Honda, S., Kurata, Y., Tomiyama, Y., Kanakura, Y. J. Thromb. Haemost. (2005)
- P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Van Kolen, K., Gilany, K., Moens, L., Esmans, E.L., Slegers, H. Cell. Signal. (2006)
- The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Savi, P., Zachayus, J.L., Delesque-Touchard, N., Labouret, C., Hervé, C., Uzabiaga, M.F., Pereillo, J.M., Culouscou, J.M., Bono, F., Ferrara, P., Herbert, J.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin: different regulations by ADP through PKA. Nasu-Tada, K., Koizumi, S., Inoue, K. Glia (2005)
- Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells. Czajkowski, R., Banachewicz, W., Ilnytska, O., Drobot, L.B., Baranska, J. Br. J. Pharmacol. (2004)
- Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Sasaki, Y., Hoshi, M., Akazawa, C., Nakamura, Y., Tsuzuki, H., Inoue, K., Kohsaka, S. Glia (2003)
- Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. Lechner, S.G., Dorostkar, M.M., Mayer, M., Edelbauer, H., Pankevych, H., Boehm, S. Eur. J. Neurosci. (2004)
- P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. Van Kolen, K., Slegers, H. J. Neurochem. (2004)
- Activity-dependent autocrine-paracrine activation of neuronal P2Y receptors. Moskvina, E., Unterberger, U., Boehm, S. J. Neurosci. (2003)
- P2 receptor-types involved in astrogliosis in vivo. Franke, H., Krügel, U., Schmidt, R., Grosche, J., Reichenbach, A., Illes, P. Br. J. Pharmacol. (2001)
- 2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12. Vasiljev, K.S., Uri, A., Laitinen, J.T. Neuropharmacology (2003)