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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UBA52  -  ubiquitin A-52 residue ribosomal protein...

Homo sapiens

Synonyms: CEP52, HUBCEP52, L40, MGC126879, MGC126881, ...
 
 
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High impact information on UBA52

  • In this study, we have used an intron sequence from the UBA52 gene for chromosome mapping studies [1].
  • Analysis of somatic cell hybrids containing individual human chromosomes indicated that the UBA52 gene is located on chromosome 19 [1].
  • Genomic hybridization analysis using probes derived from a functional UbA52 gene (UBA52) suggests that the UbA52 subfamily consists of one intron-containing, transcriptionally active gene and approximately eight processed pseudogenes, a feature characteristic of mammalian ribosomal protein gene families [2].
  • A comparison of Uba80 to Uba52 revealed that the two genes share a conserved 5'-end structure, but that the structure of the ubiquitin coding regions was not conserved [3].
 

Analytical, diagnostic and therapeutic context of UBA52

  • Northern blot analysis with a tail-specific probe indicated that the previously identified UbA mRNA species most likely represents comigrating transcripts of the 52 amino acid tail (UbA52) and 80 amino acid tail (UbA80) ubiquitin fusion genes [4].

References

  1. Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12. Webb, G.C., Baker, R.T., Coggan, M., Board, P.G. Genomics (1994) [Pubmed]
  2. The human ubiquitin/52-residue ribosomal protein fusion gene subfamily (UbA52) is composed primarily of processed pseudogenes. Baker, R.T., Board, P.G. Genomics (1992) [Pubmed]
  3. Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes. Kirschner, L.S., Stratakis, C.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes. Baker, R.T., Board, P.G. Nucleic Acids Res. (1991) [Pubmed]
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