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Gene Review

RPS27A  -  ribosomal protein S27a

Homo sapiens

Synonyms: CEP80, HEL112, S27A, UBA80, UBC, ...
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Disease relevance of RPS27A

  • The mRNA of several ribosomal proteins, and of another ubiquitin A gene fusion protein, UbA80, with an 80 amino acid extension of ribosomal protein S27a, have been reported to be over-expressed in colon cancer, but not as yet at the protein level [1].

High impact information on RPS27A

  • Using the antibodies that confirmed the presence of CEP80 in eukaryotic cells, we show here that the protein is located on ribosomes [2].
  • A comparison of Uba80 to Uba52 revealed that the two genes share a conserved 5'-end structure, but that the structure of the ubiquitin coding regions was not conserved [3].
  • Homology searches also detected the presence of a pseudogene for Uba80, and the structure of this sequence feature is also reported [3].
  • Working from a recently generated physical map of human chromosome 2p16, we determined the genetic and physical location and the genomic structure of the Uba80 gene in its entirety [3].
  • Using this approach we found an up-regulation of ubiquitin carboxyl extension protein 1 (UBCEP-1) mRNA in prostate carcinoma cells compared to the normal glandular epithelium of the prostate proper [4].

Biological context of RPS27A

  • UBCEP-1 mediated ubiquitin chain elongation may promote prostate carcinoma development by increasing via the proteasome pathway the degradation of proteins which are involved in growth inhibition or apoptosis [4].

Analytical, diagnostic and therapeutic context of RPS27A


  1. Ubiquitin fusion proteins are overexpressed in colon cancer but not in gastric cancer. Barnard, G.F., Mori, M., Staniunas, R.J., Begum, N.A., Bao, S., Puder, M., Cobb, J., Redman, K.L., Steele, G.D., Chen, L.B. Biochim. Biophys. Acta (1995) [Pubmed]
  2. Identification of the long ubiquitin extension as ribosomal protein S27a. Redman, K.L., Rechsteiner, M. Nature (1989) [Pubmed]
  3. Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes. Kirschner, L.S., Stratakis, C.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. A novel component of the ubiquitin pathway, ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer. Ko, Y., Hahn, T., Lu, H., Ma, Z.L., Chen, J., Rothe, M., Florin, A., Fronhoffs, S., Albers, P., Sachinidis, A., Vetter, H., Kaminski, A., Behrens, P., Wellmann, A., Wernert, N. Int. J. Mol. Med. (2005) [Pubmed]
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