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Gene Review

C8G  -  complement component 8, gamma polypeptide

Homo sapiens

Synonyms: Complement component C8 gamma chain
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High impact information on C8G

  • C8A and C8B are closely linked on chromosome 1p, whereas C8G is located on chromosome 9q [1].
  • The relative potencies and time courses of block by the agents (pancuronium [PC], octylguanidinium [C8G], QX-314, and 9-aminoacridine [9-AA]) were compared in different intracellular ionic solutions; specifically, the influences of internal Cs, tetramethylammonium (TMA), and Na ions on block were examined [2].
  • The human complement C8G gene, a member of the lipocalin gene family: polymorphisms and mapping to chromosome 9q34.3 [3].

Associations of C8G with chemical compounds

  • Complement component C8 is a plasma glycoprotein consisting of three nonidentical polypeptide chains (alpha, beta, gamma) which are encoded by three separate genes (C8A, C8B, C8G) [3].


  1. Genetic basis of human complement C8 beta deficiency. Kaufmann, T., Hänsch, G., Rittner, C., Späth, P., Tedesco, F., Schneider, P.M. J. Immunol. (1993) [Pubmed]
  2. Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gating. Yeh, J.Z., Oxford, G.S. J. Gen. Physiol. (1985) [Pubmed]
  3. The human complement C8G gene, a member of the lipocalin gene family: polymorphisms and mapping to chromosome 9q34.3. Dewald, G., Cichon, S., Bryant, S.P., Hemmer, S., Nöthen, M.M., Spurr, N.K. Ann. Hum. Genet. (1996) [Pubmed]
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