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C8A  -  complement component 8, alpha polypeptide

Homo sapiens

Synonyms: Complement component 8 subunit alpha, Complement component C8 alpha chain
 
 
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High impact information on C8A

  • In this study we show that mice lacking the hepatic transcription factor hepatocyte nuclear factor 1alpha (HNF1alpha) fail to transcribe C5 and C8A complement genes [1].
  • In blacks, what appears to be a third common allele was found, so that frequencies were 0.692, 0.259, and 0.049 for C8A, C8B, and C8A1 [2].
  • A BamHI RFLP of the C8A gene [3].
  • Wanting to probe the nature of this slow step in the folding of WT IL-1 beta (tau(1)=45 seconds), we made ten sequence variants of IL-1 beta (L10A, T9Q, T9G, C8S, C8A, N7G, N7D, L6A, R4P, and R4Q), where all mutations are located along strand 1 [4].
  • The comparison with the data of protein typing of the same samples proved that the described method is efficient and reliable for the identification of C8A genotypes and may be valuable for further application in population studies and forensic science [5].
 

Biological context of C8A

  • Genetic linkage analyses indicated that these loci were linked to each other and to chromosome 1 marker loci PGM1 and Rh, but it was unclear at the time if C8A was a single locus coding for a single-chain precursor form of alpha-gamma or if separate loci existed for alpha and gamma [6].
  • There was no evidence of allelic association between the C8A and C8B BamHI RFLPs in 62 unrelated haplotypes [7].
  • Our results demonstrate that HNF1alpha plays a key role in the expression of C5 and C8A genes, two terminal complement component genes that are essential for the assembly of MAC as a result of complement activation [1].
  • Two alleles, C8A and C8B, have been identified in orientals, with gene frequencies of 0.655 and 0.345 [2].
  • C8A and C8B phenotype distributions were not significantly different in the two groups [8].
 

Associations of C8A with chemical compounds

 

Other interactions of C8A

  • These were governed by separate loci designated C8A and C8B for alpha-gamma and beta, respectively [6].
 

Analytical, diagnostic and therapeutic context of C8A

References

  1. Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes. Pontoglio, M., Pausa, M., Doyen, A., Viollet, B., Yaniv, M., Tedesco, F. J. Exp. Med. (2001) [Pubmed]
  2. Genetic control of the eighth component of complement. Raum, D., Spence, M.A., Balavitch, D., Tideman, S., Merritt, A.D., Taggart, R.T., Petersen, B.H., Day, N.K., Alper, C.A. J. Clin. Invest. (1979) [Pubmed]
  3. A BamHI RFLP of the C8A gene. Rogde, S., Olaisen, B., Teisberg, P., Sodetz, J. Nucleic Acids Res. (1991) [Pubmed]
  4. Core and surface mutations affect folding kinetics, stability and cooperativity in IL-1 beta: does alteration in buried water play a role? Covalt, J.C., Roy, M., Jennings, P.A. J. Mol. Biol. (2001) [Pubmed]
  5. The eighth component of human complement: molecular basis of C8A (C81) polymorphism. Zhang, L., Rittner, C., Sodetz, J.M., Schneider, P.M., Kaufmann, T. Hum. Genet. (1995) [Pubmed]
  6. Chromosomal assignment of genes encoding the alpha, beta, and gamma subunits of human complement protein C8: identification of a close physical linkage between the alpha and the beta loci. Kaufman, K.M., Snider, J.V., Spurr, N.K., Schwartz, C.E., Sodetz, J.M. Genomics (1989) [Pubmed]
  7. Linkage and association studies with C8A and C8B RFLPs on chromosome 1. Rogde, S., Gedde-Dahl, T., Teisberg, P., Jonassen, R., Høyheim, B., Olaisen, B. Ann. Hum. Genet. (1992) [Pubmed]
  8. Genetic aspects of complement component C8 in Norwegian meningococcal disease patients. Rogde, S., Høiby, E.A., Teisberg, P., Olaisen, B. Scand. J. Infect. Dis. (1990) [Pubmed]
  9. The human complement C8G gene, a member of the lipocalin gene family: polymorphisms and mapping to chromosome 9q34.3. Dewald, G., Cichon, S., Bryant, S.P., Hemmer, S., Nöthen, M.M., Spurr, N.K. Ann. Hum. Genet. (1996) [Pubmed]
  10. Characterization, chromosomal localization, and genetic variation of the alpha subunit of porcine eighth component of complement. Nakajima, E., Itoh, T., Suzuki, K., Kawakami, K., Takeda, K., Onishi, A., Komatsu, M. Anim. Genet. (1998) [Pubmed]
  11. Solid-liquid phase behavior of binary fatty acid mixtures 3. Mixtures of oleic acid with capric acid (decanoic acid) and caprylic acid (octanoic acid). Inoue, T., Hisatsugu, Y., Suzuki, M., Wang, Z., Zheng, L. Chem. Phys. Lipids (2004) [Pubmed]
  12. C8 reference typing report and nomenclature recommendation. Rittner, C., Stradmann-Bellinghausen, B., Rogde, S. Complement and inflammation. (1990) [Pubmed]
 
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