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Gene Review

C8B  -  complement component 8, beta polypeptide

Homo sapiens

Synonyms: Complement component 8 subunit beta, Complement component C8 beta chain
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Disease relevance of C8B


High impact information on C8B


Biological context of C8B


Associations of C8B with chemical compounds


Other interactions of C8B

  • These were governed by separate loci designated C8A and C8B for alpha-gamma and beta, respectively [11].

Analytical, diagnostic and therapeutic context of C8B

  • In the patient group, one C8B deficient individual was discovered; none in the control group [7].
  • The C8-A and C8-B fractions were further purified on HPLC [10].


  1. A simplified assay for the specific diagnosis of paroxysmal nocturnal hemoglobinuria: detection of DAF(CD55)- and HRF20(CD59)- erythrocytes in microtyping cards. Nilsson, B., Hagström, U., Englund, A., Säfwenberg, J. Vox Sang. (1993) [Pubmed]
  2. Genetic control of the eighth component of complement. Raum, D., Spence, M.A., Balavitch, D., Tideman, S., Merritt, A.D., Taggart, R.T., Petersen, B.H., Day, N.K., Alper, C.A. J. Clin. Invest. (1979) [Pubmed]
  3. Genetic basis of human complement C8 beta deficiency. Kaufmann, T., Hänsch, G., Rittner, C., Späth, P., Tedesco, F., Schneider, P.M. J. Immunol. (1993) [Pubmed]
  4. A BamH1 RFLP of the C8B gene. Rogde, S., Mevåg, B., Teisberg, P., Olaisen, B., Sodetz, J. Nucleic Acids Res. (1989) [Pubmed]
  5. Human complement component C8. Molecular basis of the beta-chain polymorphism. Dewald, G., Hemmer, S., Nöthen, M.M. FEBS Lett. (1994) [Pubmed]
  6. Linkage and association studies with C8A and C8B RFLPs on chromosome 1. Rogde, S., Gedde-Dahl, T., Teisberg, P., Jonassen, R., Høyheim, B., Olaisen, B. Ann. Hum. Genet. (1992) [Pubmed]
  7. Genetic aspects of complement component C8 in Norwegian meningococcal disease patients. Rogde, S., Høiby, E.A., Teisberg, P., Olaisen, B. Scand. J. Infect. Dis. (1990) [Pubmed]
  8. C8A and C8B polymorphisms in Norwegians and Norwegian lapps. Rogde, S., Teisberg, P., Olaisen, B. Hum. Hered. (1989) [Pubmed]
  9. Detection of heterozygous C8 beta deficiency by PCR in a healthy Italian population. Bellavia, D., Schneider, P.M., Rittner, C., Malfitano, G., Kaufmann, T.J., Brai, M. Exp. Clin. Immunogenet. (1996) [Pubmed]
  10. The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. Boulias, C., Pang, H., Mastronardi, F., Moscarello, M.A. Arch. Biochem. Biophys. (1995) [Pubmed]
  11. Chromosomal assignment of genes encoding the alpha, beta, and gamma subunits of human complement protein C8: identification of a close physical linkage between the alpha and the beta loci. Kaufman, K.M., Snider, J.V., Spurr, N.K., Schwartz, C.E., Sodetz, J.M. Genomics (1989) [Pubmed]
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